On load dependence of detachment rate of kinesin motor

doi:10.1088/1674-1056/ad8ec7

中国物理B ›› 2025, Vol. 34 ›› Issue (1): 18702-018702.doi: 10.1088/1674-1056/ad8ec7

On load dependence of detachment rate of kinesin motor

Xiao-Xuan Shi(史晓璇)¹, Yao Wang(王瑶)², Yu-Ru Liu(刘玉如)², and Ping Xie(谢平)^2†

1 School of Pharmaceutical Engineering, Chongqing Chemical Industry Vocational College, Chongqing 401220, China;
2 Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China

收稿日期:2024-09-13 修回日期:2024-10-12 接受日期:2024-11-05 发布日期:2024-12-24
通讯作者: Ping Xie E-mail:pxie@iphy.ac.cn
基金资助:
Project supported by Youth Project of Science and Technology Research Program of Chongqing Education Commission of China (Grant No. KJQN202404522).

On load dependence of detachment rate of kinesin motor

Xiao-Xuan Shi(史晓璇)¹, Yao Wang(王瑶)², Yu-Ru Liu(刘玉如)², and Ping Xie(谢平)^2†

1 School of Pharmaceutical Engineering, Chongqing Chemical Industry Vocational College, Chongqing 401220, China;
2 Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China

Received:2024-09-13 Revised:2024-10-12 Accepted:2024-11-05 Published:2024-12-24
Contact: Ping Xie E-mail:pxie@iphy.ac.cn
About author:2025-018702-241333.pdf
Supported by:
Project supported by Youth Project of Science and Technology Research Program of Chongqing Education Commission of China (Grant No. KJQN202404522).

1. 2025-018702-SI.pdf(927KB)

摘要/Abstract

摘要： Kinesin is an archetypal microtubule-based molecular motor that can generate force to transport cargo in cells. The load dependence of the detachment rate is an important factor of the kinesin motor, the determination of which is critically related to the chemomechanical coupling mechanism of the motor. Here, we use three models for the load dependence of the detachment rate of the kinesin motor to study theoretically and numerically the maximal force generated and microtubule-attachment duration of the motor. By comparing the theoretical and numerical results with the available experimental data, we show that only one model can explain well the available experimental data, indicating that only this model can be applicable to the kinesin motor.

关键词: kinesin, detachment rate, generated force, chemomechanical coupling mechanism, optical trapping

Abstract: Kinesin is an archetypal microtubule-based molecular motor that can generate force to transport cargo in cells. The load dependence of the detachment rate is an important factor of the kinesin motor, the determination of which is critically related to the chemomechanical coupling mechanism of the motor. Here, we use three models for the load dependence of the detachment rate of the kinesin motor to study theoretically and numerically the maximal force generated and microtubule-attachment duration of the motor. By comparing the theoretical and numerical results with the available experimental data, we show that only one model can explain well the available experimental data, indicating that only this model can be applicable to the kinesin motor.

Key words: kinesin, detachment rate, generated force, chemomechanical coupling mechanism, optical trapping

中图分类号: (Molecular dynamics simulation)

87.10.Tf

87.15.A- (Theory, modeling, and computer simulation) 87.15.hg (Dynamics of intermolecular interactions)

Xiao-Xuan Shi(史晓璇), Yao Wang(王瑶), Yu-Ru Liu(刘玉如), and Ping Xie(谢平). On load dependence of detachment rate of kinesin motor[J]. 中国物理B, 2025, 34(1): 18702-018702.

Xiao-Xuan Shi(史晓璇), Yao Wang(王瑶), Yu-Ru Liu(刘玉如), and Ping Xie(谢平). On load dependence of detachment rate of kinesin motor[J]. Chin. Phys. B, 2025, 34(1): 18702-018702.

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On load dependence of detachment rate of kinesin motor

On load dependence of detachment rate of kinesin motor

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