中国物理B ›› 2006, Vol. 15 ›› Issue (3): 536-541.doi: 10.1088/1009-1963/15/3/015

• ATOMIC AND MOLECULAR PHYSICS • 上一篇    下一篇

A non-Markov ratchet model of molecular motors: processive movement of single-headed kinesin KIF1A

谢平, 窦硕星, 王鹏业   

  1. Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences,Beijing 100080, China
  • 收稿日期:2005-09-20 修回日期:2005-11-22 出版日期:2006-03-20 发布日期:2006-03-20
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Nos. 60025516 and 10334100).

A non-Markov ratchet model of molecular motors: processive movement of single-headed kinesin KIF1A

Xie Ping (谢平), Dou Shuo-Xing (窦硕星), Wang Peng-Ye (王鹏业)   

  1. Laboratory of Soft Matter Physics, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences,Beijing 100080, China
  • Received:2005-09-20 Revised:2005-11-22 Online:2006-03-20 Published:2006-03-20
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 60025516 and 10334100).

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摘要： A fluctuating ratchet model of non-Markov process is presented to describe the processive movement of molecular motors of single-headed kinesin KIF1A,where the fluctuation perturbation to the local potential is introduced and the detailed ATPase pathway of the motor is included. The theoretical results show good quantitative agreement with the previous experimental ones.

Abstract: A fluctuating ratchet model of non-Markov process is presented to describe the processive movement of molecular motors of single-headed kinesin KIF1A,where the fluctuation perturbation to the local potential is introduced and the detailed ATPase pathway of the motor is included. The theoretical results show good quantitative agreement with the previous experimental ones.

Key words: kinesin, model, molecular motor, kinetics

中图分类号:  (Motor proteins (myosin, kinesin dynein))

  • 87.16.Nn
87.15.H- (Dynamics of biomolecules) 87.15.K- (Molecular interactions; membrane-protein interactions) 87.15.B- (Structure of biomolecules) 87.15.Ya (Fluctuations) 87.15.R- (Reactions and kinetics)