Entrainment mechanism of the cyanobacterial circadian clock induced by oxidized quinone

doi:10.1088/1674-1056/aba615

中国物理B ›› 2020, Vol. 29 ›› Issue (9): 98703-098703.doi: 10.1088/1674-1056/aba615

Entrainment mechanism of the cyanobacterial circadian clock induced by oxidized quinone

Ying Li(李莹), Guang-Kun Zhang(张广鹍), Zi-Gen Song(宋自根)

College of Information Technology, Shanghai Ocean University, Shanghai 201306, China

收稿日期:2020-06-04 修回日期:2020-07-02 接受日期:2020-07-15 出版日期:2020-09-05 发布日期:2020-09-05
通讯作者: Ying Li E-mail:leeliying@163.com
基金资助:
Project supported by the National Natural Science Foundation of China (Grant No. 11672177).

Entrainment mechanism of the cyanobacterial circadian clock induced by oxidized quinone

Ying Li(李莹), Guang-Kun Zhang(张广鹍), Zi-Gen Song(宋自根)

College of Information Technology, Shanghai Ocean University, Shanghai 201306, China

Received:2020-06-04 Revised:2020-07-02 Accepted:2020-07-15 Online:2020-09-05 Published:2020-09-05
Contact: Ying Li E-mail:leeliying@163.com
Supported by:
Project supported by the National Natural Science Foundation of China (Grant No. 11672177).

摘要/Abstract

摘要： The circadian clock is a self-sustained biological oscillator which can be entrained by environmental signals. The cyanobacteria circadian clock is the simplest one, which is composed of the proteins KaiA, KaiB and KaiC. The phosphorylation/dephosphorylation state of KaiC exhibits a circadian oscillator. KaiA and KaiB activate KaiC phosphorylation and dephosphorylation respectively. CikA competing with KaiA for the same binding site on KaiB affects the phosphorylation state of KaiC. Quinone is a signaling molecule for entraining the cyanobacterial circadian clock which is oxidized at the onset of darkness and reduced at the onset of light, reflecting the environmental light-dark cycle. KaiA and CikA can sense external signals by detecting the oxidation state of quinone. However, the entrainment mechanism is far from clear. We develop an enhanced mathematical model including oxidized quinone sensed by KaiA and CikA, with which we present a detailed study on the entrainment of the cyanobacteria circadian clock induced by quinone signals. We find that KaiA and CikA sensing oxidized quinone pulse are related to phase advance and delay, respectively. The time of oxidized quinone pulse addition plays a key role in the phase shifts. The combination of KaiA and CikA is beneficial to the generation of entrainment, and the increase of signal intensity reduces the entrainment phase. This study provides a theoretical reference for biological research and helps us understand the dynamical mechanisms of cyanobacteria circadian clock.

关键词: mathematical model, entrainment, cyanobacterial circadian clock, phase response curve

Abstract: The circadian clock is a self-sustained biological oscillator which can be entrained by environmental signals. The cyanobacteria circadian clock is the simplest one, which is composed of the proteins KaiA, KaiB and KaiC. The phosphorylation/dephosphorylation state of KaiC exhibits a circadian oscillator. KaiA and KaiB activate KaiC phosphorylation and dephosphorylation respectively. CikA competing with KaiA for the same binding site on KaiB affects the phosphorylation state of KaiC. Quinone is a signaling molecule for entraining the cyanobacterial circadian clock which is oxidized at the onset of darkness and reduced at the onset of light, reflecting the environmental light-dark cycle. KaiA and CikA can sense external signals by detecting the oxidation state of quinone. However, the entrainment mechanism is far from clear. We develop an enhanced mathematical model including oxidized quinone sensed by KaiA and CikA, with which we present a detailed study on the entrainment of the cyanobacteria circadian clock induced by quinone signals. We find that KaiA and CikA sensing oxidized quinone pulse are related to phase advance and delay, respectively. The time of oxidized quinone pulse addition plays a key role in the phase shifts. The combination of KaiA and CikA is beneficial to the generation of entrainment, and the increase of signal intensity reduces the entrainment phase. This study provides a theoretical reference for biological research and helps us understand the dynamical mechanisms of cyanobacteria circadian clock.

Key words: mathematical model, entrainment, cyanobacterial circadian clock, phase response curve

中图分类号: (Circadian rhythms)

87.18.Yt

87.85.Tu (Modeling biomedical systems) 87.18.Vf (Systems biology)

李莹, 张广鹍, 宋自根. Entrainment mechanism of the cyanobacterial circadian clock induced by oxidized quinone[J]. 中国物理B, 2020, 29(9): 98703-098703.

Ying Li(李莹), Guang-Kun Zhang(张广鹍), Zi-Gen Song(宋自根). Entrainment mechanism of the cyanobacterial circadian clock induced by oxidized quinone[J]. Chin. Phys. B, 2020, 29(9): 98703-098703.

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Entrainment mechanism of the cyanobacterial circadian clock induced by oxidized quinone

Entrainment mechanism of the cyanobacterial circadian clock induced by oxidized quinone

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