Application of microdosimetry on biological physics for ionizing radiation

doi:10.1088/1674-1056/27/2/028701

中国物理B ›› 2018, Vol. 27 ›› Issue (2): 28701-028701.doi: 10.1088/1674-1056/27/2/028701

所属专题： TOPICAL REVIEW — Soft matter and biological physics

• SPECIAL TOPIC—Soft matter and biological physics (Review) • 上一篇下一篇

Application of microdosimetry on biological physics for ionizing radiation

Dandan Chen(陈丹丹), Liang Sun(孙亮)

1. School of Radiation Medicine and Protection, Medical College, Soochow University, Suzhou 215006, China;
2. Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215006, China;
3. Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Suzhou 215006, China

收稿日期:2017-10-08 修回日期:2017-11-30 出版日期:2018-02-05 发布日期:2018-02-05
通讯作者: Liang Sun E-mail:slhmz@126.com
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11304212 and 11575124), the Natural Science Foundation of Jiangsu Province, China (Grant Nos. BK20130279), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), and the International Thermonuclear Experimental Reactor (ITER) Special Program of China (Grant No. 2014GB112006).

Application of microdosimetry on biological physics for ionizing radiation

Dandan Chen(陈丹丹)^1,2,3, Liang Sun(孙亮)^1,2,3

1. School of Radiation Medicine and Protection, Medical College, Soochow University, Suzhou 215006, China;
2. Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou 215006, China;
3. Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Suzhou 215006, China

Received:2017-10-08 Revised:2017-11-30 Online:2018-02-05 Published:2018-02-05
Contact: Liang Sun E-mail:slhmz@126.com
About author:87.10.Mn; 87.10.Rt; 87.57.uq
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11304212 and 11575124), the Natural Science Foundation of Jiangsu Province, China (Grant Nos. BK20130279), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), and the International Thermonuclear Experimental Reactor (ITER) Special Program of China (Grant No. 2014GB112006).

摘要/Abstract

摘要：

Stochastic characterization of radiation interaction is of importance to cell damage. Microdosimetry is to investigate the random structures of particle tracks in order to understand the dose-effect in cellular scales. In the review, we introduced the basic concepts of microdosimetry as well as the experimental methods (TEPC) and Monte Carlo simulations. Three basic biophysical models are interpreted and compared, including the target model, linear-quadratic model, and microdosimetric-kinetic model. The bottlenecks in the current microdosimetry research are also discussed, which need the interdisciplinary contributions from biology, physics, mathematics, computer science and electric engineering.

关键词: microdosimetry, biophysics, radiation protection

Abstract:

Key words: microdosimetry, biophysics, radiation protection

中图分类号: (Stochastic modeling)

87.10.Mn

87.10.Rt (Monte Carlo simulations) 87.57.uq (Dosimetry)

陈丹丹, 孙亮. Application of microdosimetry on biological physics for ionizing radiation[J]. 中国物理B, 2018, 27(2): 28701-028701.

Dandan Chen(陈丹丹), Liang Sun(孙亮). Application of microdosimetry on biological physics for ionizing radiation[J]. Chin. Phys. B, 2018, 27(2): 28701-028701.

参考文献 34

[1]	Newhauser W D and Durante M 2011 Nat. Rev. Cancer 11 438
[2]	International Commission on Radiological Protection 2004 Nuclear Standard Measurement and Quality 4 41(in Chinese)
[3]	Cucinotta F A 2014 PLoS One 9 96099
[4]	Cardis E, Vrijheid M, Blettner M et al. 2005 BMJ 331 77
[5]	Leuraud K, Richardson D B, Cardis E, Daniels R D, Gillies M,O'Hagan J A, Hamra G B, Haylock R, Laurier D, Moissonnier M,Schubauer-Berigan M K, Thierry-Chef I and Kesminiene A 2015 Lancet 2 276
[6]	International Commission on Radiological Protection 1991 Ann. ICRP 20 1
[7]	Standardization Administration of the People's Republic of China 2002 Basic standards for protection against ionizing radiation and for the safety of radiation sources GB18871-2002(in Chinese)
[8]	Zhuo F 2004 Nuclear Standard Measurement and Quality 4 41(in Chinese)
[9]	Dauer L T, Brooks A L, Hoel D G, Morgan W F, Stram D and Tran P 2010 Radiat. Prot. Dosim. 140 103
[10]	Grant E J, Brenner A, Sugiyama H, Sakata R, Sadakane A, Utada M, Cahoon E K, Milder C M, Soda M, Cullings H M, Preston D L, Mabuchi K and Ozasa K 2017 Radiat. Res. 187 513
[11]	Dropkin G 2016 Environ. Health 15 112
[12]	Walsh L and Zhang W 2016 Radiat. Environ. Biophys. 55 9
[13]	International Commission on Radiation Units and Measurements 1983 ICRU Report 36
[14]	Kase K R, Bjarngard B E and Attix F H 1985 The dosimetry of ionizing radiation, Vol. I (Academic press, INC)
[15]	Yin X, Tian W, Wang L, Wang J, Zhang S, Cao J and Yang H 2015 Sci. Rep. 5 11373
[16]	Rossi H H 1979 Radiat. Environ. Biophys. 17 29
[17]	Rossi H H 1960 Radiat. Res. 2 290
[18]	Cacao E, Hada M, Saganti P B, George K A and Cucinotta F A 2016 PLoS One 11 e0153998
[19]	Hawkins R B 1998 Med. Phys. 5 1157
[20]	Hawkins R B 1996 Int. J. Radiat. Biol. 69 739
[21]	Hawkins R B 2003 Radiat. Res. 160 61
[22]	Kase Y, Kanai T and Matsumoto Y 2006 Radiat. Res. 166 629
[23]	Иванов В И and Hua M 1987 Microdosimetry (Beijing:Atomic Energy Press) p. 12(in Chinese)
[24]	Lindborg L and Nikjoo H 2011 Radiat. Prot. Dosim. 143 402
[25]	Stewart R D, Streitmatter S W, Argento D C, Kirkby C, Goorley J T, Moffitt G, Jevremovic T and Sandison G A 2015 Phys. Med. Biol. 60 8249
[26]	Incerti S, Douglass M, Penfold S, Guatelli S and Bezak E 2016 Phys. Med. 32 1187
[27]	Mancusi D, Sihver L, Gustafsson K, La Tessa C, Guetersloh S B, Zeitlin C J, Miller J, Heilbronn L H, Niita K, Sato T, Nakashima H, Murakami T and Iwata Y 2007 Nucl. Instrum. Method B 254 30
[28]	Sihver L, Ni J, Sun L, Kong D, Ren Y and Gu S 2014 Radiat. Environ. Biophys. 53 571
[29]	Wang X, Li J, Wu Z, Qiu R, Li C, Liang M, Zhang H, Gang Z and Xu H 2017 Chin. Phys. C 41 014103
[30]	Liu Q, Liu H, Chen B, Kong Y, Hu P and Zhuo W 2015 Chin. J. Med. Phys. 32 629(in Chinese)
[31]	Li J, Li C, Qiu R, Yan C, Xie W, Wu Zhen, Zeng Z and Tung C 2015 Radiat. Prot. Dosim 166 38
[32]	Rossi H H 1977 Radiat. Res. 71 1
[33]	Fowler J F 2010 Brit. J. Radiol. 83 554
[34]	Badhwar G D, Robbins D E, Gibbons F and Braby L A 2002 Radiat. Meas. 35 551

Application of microdosimetry on biological physics for ionizing radiation

Application of microdosimetry on biological physics for ionizing radiation

RichHTML

PDF (PC)

赞

可视化

摘要/Abstract

引用本文

使用本文

参考文献 34

相关文章 2

Metrics

本文评价

推荐阅读 0

[1]	王一舟, 侯锡苗, 车海鹏, 肖雪, 奚绪光, 窦硕星, 王鹏业, 李伟. Interaction between human telomeric G-quadruplexes characterized by single molecule magnetic tweezers[J]. 中国物理B, 2018, 27(6): 68701-068701.
[2]	牛燕雄, 杨海林, 张鹏, 沈学举, 姜楠, 陈燕, 唐芳. Study on the optical limiting properties of the mixed liquid of carbon black suspensions and green tea solution by multi-pulse laser[J]. 中国物理B, 2008, 17(9): 3367-3371.