中国物理B ›› 2016, Vol. 25 ›› Issue (12): 128703-128703.doi: 10.1088/1674-1056/25/12/128703

• INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇    下一篇

Accuracy and effectiveness of self-gating signals in free-breathing three-dimensional cardiac cine magnetic resonance imaging

Shuo Li(李硕), Lei Wang(王磊), Yan-Chun Zhu(朱艳春), Jie Yang(杨洁), Yao-Qin Xie(谢耀钦), Nan Fu(付楠), Yi Wang(王乙), Song Gao(高嵩)   

  1. 1. Medical Imaging Physics Laboratory, Health Science Center, Peking University, Beijing 100191, China;
    2. Department of Orthopedic Surgery, People's Hospital of Luohu, Shenzhen University, Shenzhen 518001, China;
    3. Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;
    4. Department of Radiology, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA
  • 收稿日期:2016-05-19 修回日期:2016-08-17 出版日期:2016-12-05 发布日期:2016-12-05
  • 通讯作者: Yan-Chun Zhu E-mail:yc.zhu@siat.ac.cn
  • 基金资助:

    Project supported by the National Natural Science Foundation of China (Grant Nos. 81501463, 61471349, 81671853, 81571669, and 61671026), the National High Technology Research and Development Program of China (Grant No. 2015AA043203), the Natural Science Foundation of Beijing, China (Grant No. 7162112), Guangdong Innovative Research Team Program of China (Grant No. 2011S013), the Natural Science Foundation of Guangdong Province, China (Grant Nos. 2014A030310360 and 2014A0202015028), the Beijing Center for Mathematics and Information Interdisciplinary Sciences, Shenzhen Fundamental Research Program, China (Grant Nos. JCYJ201500731154850923 and JCYJ20140417113430665), Shenzhen High-level Oversea Talent Program, China (Grant No. KQJSCX20160301144248), and the Nanshan Technology Research Fund, China (Grant No. KC2014JSQN0001A).

Accuracy and effectiveness of self-gating signals in free-breathing three-dimensional cardiac cine magnetic resonance imaging

Shuo Li(李硕)1,3, Lei Wang(王磊)2, Yan-Chun Zhu(朱艳春)3,4, Jie Yang(杨洁)3, Yao-Qin Xie(谢耀钦)3, Nan Fu(付楠)3, Yi Wang(王乙)4, Song Gao(高嵩)1   

  1. 1. Medical Imaging Physics Laboratory, Health Science Center, Peking University, Beijing 100191, China;
    2. Department of Orthopedic Surgery, People's Hospital of Luohu, Shenzhen University, Shenzhen 518001, China;
    3. Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;
    4. Department of Radiology, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA
  • Received:2016-05-19 Revised:2016-08-17 Online:2016-12-05 Published:2016-12-05
  • Contact: Yan-Chun Zhu E-mail:yc.zhu@siat.ac.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Grant Nos. 81501463, 61471349, 81671853, 81571669, and 61671026), the National High Technology Research and Development Program of China (Grant No. 2015AA043203), the Natural Science Foundation of Beijing, China (Grant No. 7162112), Guangdong Innovative Research Team Program of China (Grant No. 2011S013), the Natural Science Foundation of Guangdong Province, China (Grant Nos. 2014A030310360 and 2014A0202015028), the Beijing Center for Mathematics and Information Interdisciplinary Sciences, Shenzhen Fundamental Research Program, China (Grant Nos. JCYJ201500731154850923 and JCYJ20140417113430665), Shenzhen High-level Oversea Talent Program, China (Grant No. KQJSCX20160301144248), and the Nanshan Technology Research Fund, China (Grant No. KC2014JSQN0001A).

摘要:

Conventional multiple breath-hold two-dimensional (2D) balanced steady-state free precession (SSFP) presents many difficulties in cardiac cine magnetic resonance imaging (MRI). Recently, a self-gated free-breathing three-dimensional (3D) SSFP technique has been proposed as an alternative in many studies. However, the accuracy and effectiveness of self-gating signals have been barely studied before. Since self-gating signals are crucially important in image reconstruction, a systematic study of self-gating signals and comparison with external monitored signals are needed.
Previously developed self-gated free-breathing 3D SSFP techniques are used on twenty-eight healthy volunteers. Both electrocardiographic (ECG) and respiratory bellow signals are also acquired during the scan as external signals. Self-gating signal and external signal are compared by trigger and gating window. Gating window is proposed to evaluate the accuracy and effectiveness of respiratory self-gating signal. Relative deviation of the trigger and root-mean-square-deviation of the cycle duration are calculated. A two-tailed paired t-test is used to identify the difference between self-gating and external signals. A Wilcoxon signed rank test is used to identify the difference between peak and valley self-gating triggers.
The results demonstrate an excellent correlation (P=0, R>0.99) between self-gating and external triggers. Wilcoxon signed rank test shows that there is no significant difference between peak and valley self-gating triggers for both cardiac (H=0, P>0.10) and respiratory (H=0, P>0.44) motions. The difference between self-gating and externally monitored signals is not significant (two-tailed paired-sample t-test:H=0, P>0.90).
The self-gating signals could demonstrate cardiac and respiratory motion accurately and effectively as ECG and respiratory bellow. The difference between the two methods is not significant and can be explained. Furthermore, few ECG trigger errors appear in some subjects while these errors are not found in self-gating signals.

关键词: self-gating, free-breathing, cine MRI, effectiveness, accuracy

Abstract:

Conventional multiple breath-hold two-dimensional (2D) balanced steady-state free precession (SSFP) presents many difficulties in cardiac cine magnetic resonance imaging (MRI). Recently, a self-gated free-breathing three-dimensional (3D) SSFP technique has been proposed as an alternative in many studies. However, the accuracy and effectiveness of self-gating signals have been barely studied before. Since self-gating signals are crucially important in image reconstruction, a systematic study of self-gating signals and comparison with external monitored signals are needed.
Previously developed self-gated free-breathing 3D SSFP techniques are used on twenty-eight healthy volunteers. Both electrocardiographic (ECG) and respiratory bellow signals are also acquired during the scan as external signals. Self-gating signal and external signal are compared by trigger and gating window. Gating window is proposed to evaluate the accuracy and effectiveness of respiratory self-gating signal. Relative deviation of the trigger and root-mean-square-deviation of the cycle duration are calculated. A two-tailed paired t-test is used to identify the difference between self-gating and external signals. A Wilcoxon signed rank test is used to identify the difference between peak and valley self-gating triggers.
The results demonstrate an excellent correlation (P=0, R>0.99) between self-gating and external triggers. Wilcoxon signed rank test shows that there is no significant difference between peak and valley self-gating triggers for both cardiac (H=0, P>0.10) and respiratory (H=0, P>0.44) motions. The difference between self-gating and externally monitored signals is not significant (two-tailed paired-sample t-test:H=0, P>0.90).
The self-gating signals could demonstrate cardiac and respiratory motion accurately and effectively as ECG and respiratory bellow. The difference between the two methods is not significant and can be explained. Furthermore, few ECG trigger errors appear in some subjects while these errors are not found in self-gating signals.

Key words: self-gating, free-breathing, cine MRI, effectiveness, accuracy

中图分类号:  (Magnetic resonance imaging)

  • 87.61.-c
87.57.-s (Medical imaging)