Fluctuation theorem for the mutation process in  in vitro  evolution

doi:10.1088/1674-1056/19/4/040202

中国物理B ›› 2010, Vol. 19 ›› Issue (4): 40202-40202.doi: 10.1088/1674-1056/19/4/040202

Fluctuation theorem for the mutation process in in vitro evolution

汤超¹, 刘琪², 欧阳颀²

(1)Center for Theoretical Biology, Peking University, Beijing {\rm 100871, China;California Institute for Quantitative Biomedical Research, Departments of Biopharmaceutical Sciences and Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA; (2)Department of Physics, Peking University, Beijing 100871, China;Center for Theoretical Biology, Peking University, Beijing {\rm 100871, China

收稿日期:2009-06-29 修回日期:2009-09-17 出版日期:2010-04-15 发布日期:2010-04-15
基金资助:
Project supported by the National Natural Science Foundation of China (Grant No.~10721403), the National Basic Research Program of China (Grant No.~2007CB814802), and the Jun-Zheng Foundation at Peking University.

Fluctuation theorem for the mutation process in in vitro evolution

Liu Qi(刘琪)^a)b), Tang Chao(汤超)^b)c), and Ouyang Qi(欧阳颀)^a)b)†

^a Department of Physics, Peking University, Beijing 100871, China; ^b Center for Theoretical Biology, Peking University, Beijing 100871, China; ^c California Institute for Quantitative Biomedical Research, Departments of Biopharmaceutical Sciences and Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA

Received:2009-06-29 Revised:2009-09-17 Online:2010-04-15 Published:2010-04-15
Supported by:
Project supported by the National Natural Science Foundation of China (Grant No.~10721403), the National Basic Research Program of China (Grant No.~2007CB814802), and the Jun-Zheng Foundation at Peking University.

摘要/Abstract

摘要： A proposition based on the fluctuation theorem in thermodynamics is formulated to quantitatively describe molecular evolution processes in biology. Although we cannot give full proof of its generality, we demonstrate via computer simulation its applicability in an example of DNA in vitro evolution. According to this theorem, the evolution process is a series of exponentially rare fluctuations fixed by the force of natural selection.

Abstract: A proposition based on the fluctuation theorem in thermodynamics is formulated to quantitatively describe molecular evolution processes in biology. Although we cannot give full proof of its generality, we demonstrate via computer simulation its applicability in an example of DNA in vitro evolution. According to this theorem, the evolution process is a series of exponentially rare fluctuations fixed by the force of natural selection.

Key words: fluctuation theorem, molecular evolution, natural selection

中图分类号: (Fluctuations)

87.15.Ya

87.17.-d (Cell processes) 87.23.Kg (Dynamics of evolution) 87.14.G- (Nucleic acids) 87.15.A- (Theory, modeling, and computer simulation) 87.19.Pp (Biothermics and thermal processes in biology)

刘琪, 汤超, 欧阳颀. Fluctuation theorem for the mutation process in in vitro evolution[J]. 中国物理B, 2010, 19(4): 40202-40202.

Liu Qi(刘琪), Tang Chao(汤超), and Ouyang Qi(欧阳颀). Fluctuation theorem for the mutation process in in vitro evolution[J]. Chin. Phys. B, 2010, 19(4): 40202-40202.

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Fluctuation theorem for the mutation process in in vitro evolution

Fluctuation theorem for the mutation process in in vitro evolution

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