中国物理B ›› 2010, Vol. 19 ›› Issue (2): 20503-020503.doi: 10.1088/1674-1056/19/2/020503

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A simplified tether model for molecular motor transporting cargo

李防震, 蒋立春   

  1. School of Computer Science & Engineering, Shandong Economic University, Jinan 250014, China
  • 收稿日期:2008-08-12 修回日期:2009-04-24 出版日期:2010-02-15 发布日期:2010-02-15
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant No.~30600121) and Doctoral Foundation of Shandong Province of China (Grant No.~2007BS09002).

A simplified tether model for molecular motor transporting cargo

Li Fang-Zhen(李防震) and Jiang Li-Chun (蒋立春)   

  1. School of Computer Science & Engineering, Shandong Economic University, Jinan 250014, China
  • Received:2008-08-12 Revised:2009-04-24 Online:2010-02-15 Published:2010-02-15
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant No.~30600121) and Doctoral Foundation of Shandong Province of China (Grant No.~2007BS09002).

摘要: Molecular motors are proteins or protein complexes which function as transporting engines in biological cells. This paper models the tether between motor and its cargo as a symmetric linear potential. Different from Elston and Peskin's work for which performance of the system was discussed only in some limiting cases, this study produces analytic solutions of the problem for general cases by simplifying the transport system into two physical states, which makes it possible to discuss the dynamics of the motor--cargo system in detail. It turns out that the tether strength between motor and cargo should be greater than a threshold or the motor will fail to transport the cargo, which was not discussed by former researchers yet. Value of the threshold depends on the diffusion coefficients of cargo and motor and also on the strength of the Brownian ratchets dragging the system. The threshold approaches a finite constant when the strength of the ratchet tends to infinity.

Abstract: Molecular motors are proteins or protein complexes which function as transporting engines in biological cells. This paper models the tether between motor and its cargo as a symmetric linear potential. Different from Elston and Peskin's work for which performance of the system was discussed only in some limiting cases, this study produces analytic solutions of the problem for general cases by simplifying the transport system into two physical states, which makes it possible to discuss the dynamics of the motor--cargo system in detail. It turns out that the tether strength between motor and cargo should be greater than a threshold or the motor will fail to transport the cargo, which was not discussed by former researchers yet. Value of the threshold depends on the diffusion coefficients of cargo and motor and also on the strength of the Brownian ratchets dragging the system. The threshold approaches a finite constant when the strength of the ratchet tends to infinity.

Key words: molecular motor, Brownian ratchet, symmetric linear potential, motor--cargo system

中图分类号:  (Motor proteins (myosin, kinesin dynein))

  • 87.16.Nn
87.15.Vv (Diffusion) 87.16.A- (Theory, modeling, and simulations)