中国物理B ›› 1994, Vol. 3 ›› Issue (7): 539-549.doi: 10.1088/1004-423X/3/7/008

• 8000 CROSSDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇    

INVESTIGATION OF THERMAL DENATURATION OF DNA MOLECULES BASED ON LANGEVIN EQUATION APPROACH

杨会杰, 卓益忠, 吴锡真   

  1. Institute of Atomic Energy, Beijing 102413, China
  • 收稿日期:1993-06-24 出版日期:1994-07-20 发布日期:1994-07-20

INVESTIGATION OF THERMAL DENATURATION OF DNA MOLECULES BASED ON LANGEVIN EQUATION APPROACH

YANG HUI-JIE (杨会杰), ZHUO YI-ZHONG (卓益忠), WU XI-ZHEN (吴锡真)   

  1. Institute of Atomic Energy, Beijing 102413, China
  • Received:1993-06-24 Online:1994-07-20 Published:1994-07-20

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摘要： In this paper, by using non-equilibrium transport theory, the thermal denaturation of DNA molecules is investigated as a preliminary step to clarify the dynamical process of DNA transcription, The distribution functions of the displacement of base pairs at different temperatures are calculated. A modified model is also proposed which can reproduce the essential features of the denaturation process, Calculations show that Langevin equation is an effective tool for describing the dynamical process of DNA molecules and it seems to be more advantageous over the Nosé method.

Abstract: In this paper, by using non-equilibrium transport theory, the thermal denaturation of DNA molecules is investigated as a preliminary step to clarify the dynamical process of DNA transcription, The distribution functions of the displacement of base pairs at different temperatures are calculated. A modified model is also proposed which can reproduce the essential features of the denaturation process, Calculations show that Langevin equation is an effective tool for describing the dynamical process of DNA molecules and it seems to be more advantageous over the Nosé method.

中图分类号:  (Nucleic acids)

  • 87.14.G-
87.15.A- (Theory, modeling, and computer simulation) 87.15.H- (Dynamics of biomolecules)