Assessment of cortical bone fatigue using coded nonlinear ultrasound

doi:10.1088/1674-1056/ac0db2

中国物理B ›› 2021, Vol. 30 ›› Issue (9): 94301-094301.doi: 10.1088/1674-1056/ac0db2

Assessment of cortical bone fatigue using coded nonlinear ultrasound

Duwei Liu(刘度为)¹, Boyi Li(李博艺)^2,†, Dongsheng Bi(毕东生)¹, Tho N. H. T. Tran², Yifang Li(李义方)^1,3, Dan Liu(刘丹)¹, Ying Li(李颖)¹, and Dean Ta(他得安)^1,2,‡

1 Center for Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai 200433, China;
2 Academy for Engineering and Technology, Fudan University, Shanghai 200433, China;
3 Human Phenome Institute, Fudan University, Shanghai 200433, China

收稿日期:2021-04-08 修回日期:2021-06-16 接受日期:2021-06-23 出版日期:2021-08-19 发布日期:2021-09-02
通讯作者: Boyi Li, Dean Ta E-mail:liboyi@fudan.edu.cn;tda@fudan.edu.cn
基金资助:
Project supported by the China Postdoctoral Science Foundation (Grant No. 2021M690709), the National Natural Science Foundation of China (Grant Nos. 11827808, 11874289, 11804056, and 12034005), the Program of Shanghai Academic Research Leader (Grant No. 19XD1400500), and the Project of Shanghai Science and Technology Innovation Plan (Grant No. 19441903400).

Assessment of cortical bone fatigue using coded nonlinear ultrasound

Duwei Liu(刘度为)¹, Boyi Li(李博艺)^2,†, Dongsheng Bi(毕东生)¹, Tho N. H. T. Tran², Yifang Li(李义方)^1,3, Dan Liu(刘丹)¹, Ying Li(李颖)¹, and Dean Ta(他得安)^1,2,‡

1 Center for Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai 200433, China;
2 Academy for Engineering and Technology, Fudan University, Shanghai 200433, China;
3 Human Phenome Institute, Fudan University, Shanghai 200433, China

Received:2021-04-08 Revised:2021-06-16 Accepted:2021-06-23 Online:2021-08-19 Published:2021-09-02
Contact: Boyi Li, Dean Ta E-mail:liboyi@fudan.edu.cn;tda@fudan.edu.cn
Supported by:
Project supported by the China Postdoctoral Science Foundation (Grant No. 2021M690709), the National Natural Science Foundation of China (Grant Nos. 11827808, 11874289, 11804056, and 12034005), the Program of Shanghai Academic Research Leader (Grant No. 19XD1400500), and the Project of Shanghai Science and Technology Innovation Plan (Grant No. 19441903400).

摘要/Abstract

摘要： Bone fatigue accumulation is a factor leading to bone fracture, which is a progressive process of microdamage deteriorating under long-term and repeated stress. Since the microdamage of the early stage in bone is difficult to be investigated by linear ultrasound, the second harmonic generation method in nonlinear ultrasound technique is employed in this paper, which is proved to be more sensitive to microdamage. To solve the deficiency that the second harmonic component is easily submerged by noise in traditional nonlinear measurement, a weighted chirp coded sinusoidal signal was applied as the ultrasonic excitation, while pulse inversion is implemented at the receiving side. The effectiveness of this combination to improve the signal-to-noise ratio has been demonstrated by in vitro experiment. Progressive fatigue loading experiments were conducted on the cortical bone plate in vitro for microdamage generation. There was a significant increase in the slope of the acoustic nonlinearity parameter with the propagation distance (increased by 8% and 24% respectively) when the bone specimen was at a progressive level of microdamage. These results indicate that the coded nonlinear ultrasonic method might have the potential in diagnosing bone fatigue.

关键词: nonlinear ultrasonic Lamb wave, bone fatigue, chirp code, pulse inversion

Abstract: Bone fatigue accumulation is a factor leading to bone fracture, which is a progressive process of microdamage deteriorating under long-term and repeated stress. Since the microdamage of the early stage in bone is difficult to be investigated by linear ultrasound, the second harmonic generation method in nonlinear ultrasound technique is employed in this paper, which is proved to be more sensitive to microdamage. To solve the deficiency that the second harmonic component is easily submerged by noise in traditional nonlinear measurement, a weighted chirp coded sinusoidal signal was applied as the ultrasonic excitation, while pulse inversion is implemented at the receiving side. The effectiveness of this combination to improve the signal-to-noise ratio has been demonstrated by in vitro experiment. Progressive fatigue loading experiments were conducted on the cortical bone plate in vitro for microdamage generation. There was a significant increase in the slope of the acoustic nonlinearity parameter with the propagation distance (increased by 8% and 24% respectively) when the bone specimen was at a progressive level of microdamage. These results indicate that the coded nonlinear ultrasonic method might have the potential in diagnosing bone fatigue.

Key words: nonlinear ultrasonic Lamb wave, bone fatigue, chirp code, pulse inversion

中图分类号: (Parameters of nonlinearity of the medium)

43.25.Ba

43.60.Ek (Acoustic signal coding, morphology, and transformation) 43.80.Ev (Acoustical measurement methods in biological systems and media) 62.20.me (Fatigue)

Duwei Liu(刘度为), Boyi Li(李博艺), Dongsheng Bi(毕东生), Tho N. H. T. Tran, Yifang Li(李义方), Dan Liu(刘丹), Ying Li(李颖), and Dean Ta(他得安). Assessment of cortical bone fatigue using coded nonlinear ultrasound[J]. 中国物理B, 2021, 30(9): 94301-094301.

参考文献

[1] Loundagin L L, Schmidt T A and Edwards W B 2018 J. Biomech. Eng. 140 031003
[2] Li J and Gong H 2020 Acta Mech. Sin. 37 516
[3] Shaktivesh S, Malekipour F, Whitton R C, Hitchens P L and Lee P V S 2020 J. Mech. Behav. Biomed. Mater. 110 103920
[4] Haupert S, Guerard S, Peyrin F, Mitton D and Laugier P 2014 PLoS One 9 e83599
[5] Voide R, Schneider P, Stauber M, van Lenthe G H, Stampanoni M and Müller R 2011 Bone 49 1186
[6] Larrue A, Rattner A, Peter Z A, Olivier C, Laroche N, Vico L and Peyrin F 2011 PLoS One 6 e21297
[7] Rue J P H, Armstrong Iii D W, Frassica F J, Deafenbaugh M and Wilckens J H 2004 Orthopedics 27 1192
[8] Moilanen P, Kilappa V, Nicholson P H F, Timonen J and Cheng S 2004 Ultrasound Med. Biol. 30 1517
[9] Bossy E, Talmant M, Peyrin F, Akrout L, Cloetens P and Laugier P 2004 J. Bone Miner. Res. 19 1548
[10] Raum K, Leguerney I, Chandelier F, Bossy E and Laugier P 2005 Ultrasound Med. Biol. 31 1225
[11] Bennell K L, Hart P, Nattrass C and Wark J D 1998 Calcif. Tissue Int. 63 505
[12] Renaud G, Callé S, Remenieras J P, Mitton D and Defontaine M 2009 J. Acous. Soc. Am. 123 3633
[13] Wang R, Wu Q, Yu F, Okabe Y and Xiong K 2019 Struct Health Monit. 18 869
[14] Wan X, Tse P, Xu G, Tao T and Zhang Q 2016 Smart Mater. Struct. 25 045023
[15] Chillara V K and Lissenden C 2015 Opt Eng. 55 011002
[16] Wan X, Peter W T, Zhang X, Xu G, Zhang Q, Fan H, Mao Q, Dong M, Wang C and Ma H 2018 Smart Mater. Struct. 27 045006
[17] Gao X and Qu J 2018 J. Appl. Phys. 124 125102
[18] Hikata A, Chick B B and Elbaum C 1965 J. Appl. Phys. 36 229
[19] Cantrell J H and Yost W T 1997 J. Appl. Phys. 81 2957
[20] Matlack K H, Bradley H A, Thiele S, Kim J Y and Jacobs L J 2015 NDT and E Int. 71 8
[21] Jhang K Y 2009 Int. J. Precis. Eng. Man. 10 123
[22] Nazarov V E and Sutin A M 1997 J. Acous. Soc. Am. 102 3349
[23] Muller M, Mitton D, Talmant M, Johnson P and Laugier P 2008 J. Biomech. 41 1062
[24] Renaud G, Calle S, Remenieras J P and Defontaine M 2008 IEEE Trans. Ultrason Ferroelectr. Freq. Control 55 1497
[25] Ulrich T, Johnson P A, Müller M, Mitton D, Talmant M and Laugier P 2007 Appl. Phys. Lett. 91 213901
[26] Engan H, Ingebrigtsen K, Oygarden K, Hagen E and Hoff L 2006 IEEE International Ultrasonics Symposium (IUS), October, Vaucouver, BC, Canada, pp. 2096-2099
[27] Hoff L, Oygarden K, Hagen E K and Falch J A 2003 IEEE International Ultrasonics Symposium (IUS), October, Honolulu, HI, USA, pp. 1010-1013
[28] Matlack K H, Kim J Y, Jacobs L J and Qu J 2014 J. Nondestruct. Eval. 34 273
[29] Zacharias K, Balabanidou E, Hatzokos I, Rekanos I T and Trochidis A 2009 J. Biomech. 42 581
[30] Pruell C, Kim J Y, Qu J and Jacobs L J 2009 Smart Mater. Struct. 18 035003
[31] Gian, Piero, Malfense, Fierro, Michele and Meo 2019 Ultrasonics 93 43
[32] Marie M, Alexander S, Robert G, Maryline T, Pascal L and Johnson P A 2005 J. Acous. Soc. Am. 118 3946
[33] Haupert S, Guérard S, Pa J, Mitton D and Laugier P 2011 IEEE International Ultrasonics Symposium (IUS), October, Orlando, FL, USA, pp. 1024-1027
[34] Lee K I 2016 J. Acous. Soc. Am. 140 EL528
[35] Matlack K H, Kim J Y, Jacobs L J and Qu J 2011 J. Appl. Phys. 109 014905
[36] Chiao R Y and Hao X 2005 IEEE Trans. Ultrason Ferroelectr. Freq. Control 52 160
[37] Nowicki A, Litniewski J, Secomski W, Lewin P A and Trots I 2004 Ultrasonics 41 615
[38] Zhang H, Wu S, Ta D, Xu K and Wang W 2014 Ultrasonics 54 1203
[39] de Lima W J N and Hamilton M F 2003 J. Sound Vib. 265 819
[40] Deng M 2003 J. Appl. Phys. 94 4152
[41] Liu Y, Chillara V K and Lissenden C J 2013 J. Sound Vib. 332 4517
[42] Martin F M, Jin-Yeon K, Qu J and Laurence J J 2010 J. Acous. Soc. Am. 127 2141
[43] Michaels J E, Lee S J, Croxford A J and Wilcox P D 2013 Ultrasonics 53 265
[44] Chen H L, Deng F and Zhang X 2013 Adv. Mat. Res. 846-847 826
[45] Michaels J E, Lee S J, Hall J S and Michaels T E 2011 Proceedings of SPIE - The International Society for Optical Engineering 7984 15
[46] Matsuda N and Biwa S 2014 J. Nondestruct. Eval. 33 169
[47] Kim D Y, Lee J C, Kwon S J and Song T K 2001 IEEE International Ultrasonics Symposium (IUS), October, Atlanta, GA, USA, pp. 1477-1480
[48] Song J, Chang J H, Song T K and Yoo Y 2011 Ultrasonics 51 516
[49] Song J, Kim S, Sohn H Y, Song T K and Yoo Y M 2010 Ultrasonics 50 613
[50] Pattin C A, Caler W E and Carter D R 1996 J. Biomech. 29 69
[51] Lambers F M, Bouman A R, Tkachenko E V, Keaveny T M and Hernandez C J 2014 J. Biomech. 47 3605
[52] Taylor D 2010 J. Orthop. Res. 16 163
[53] Arif M, Ali M A, Shaikh M M and Freear S 2017 Ultrasound Med. Biol. 43 1690
[54] Bai L, Xu K L, Li D, Ta D A, Le L H and Wang W Q 2018 J. Biomech. 77 83

Assessment of cortical bone fatigue using coded nonlinear ultrasound

Assessment of cortical bone fatigue using coded nonlinear ultrasound

RichHTML

PDF (PC)

赞

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

Metrics

本文评价

推荐阅读 0