Second harmonic magnetoacoustic responses of magnetic nanoparticles in magnetoacoustic tomography with magnetic induction

doi:10.1088/1674-1056/ab6843

中国物理B ›› 2020, Vol. 29 ›› Issue (3): 34302-034302.doi: 10.1088/1674-1056/ab6843

• ELECTROMAGNETISM, OPTICS, ACOUSTICS, HEAT TRANSFER, CLASSICAL MECHANICS, AND FLUID DYNAMICS • 上一篇下一篇

Second harmonic magnetoacoustic responses of magnetic nanoparticles in magnetoacoustic tomography with magnetic induction

Gepu Guo(郭各朴), Ya Gao(高雅), Yuzhi Li(李禹志), Qingyu Ma(马青玉), Juan Tu(屠娟), Dong Zhang(章东)

1 School of Physics and Technology, Nanjing Normal University, Nanjing 210023, China;
2 Institute of Acoustics, Nanjing University, Nanjing 210093, China

收稿日期:2019-11-17 修回日期:2019-12-14 出版日期:2020-03-05 发布日期:2020-03-05
通讯作者: Qingyu Ma E-mail:maqingyu@njnu.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11934009, 11974187, and 11604156).

Second harmonic magnetoacoustic responses of magnetic nanoparticles in magnetoacoustic tomography with magnetic induction

Gepu Guo(郭各朴)¹, Ya Gao(高雅)¹, Yuzhi Li(李禹志)¹, Qingyu Ma(马青玉)¹, Juan Tu(屠娟)², Dong Zhang(章东)²

1 School of Physics and Technology, Nanjing Normal University, Nanjing 210023, China;
2 Institute of Acoustics, Nanjing University, Nanjing 210093, China

Received:2019-11-17 Revised:2019-12-14 Online:2020-03-05 Published:2020-03-05
Contact: Qingyu Ma E-mail:maqingyu@njnu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11934009, 11974187, and 11604156).

摘要/Abstract

摘要： Due to the unique magnetic, mechanical and thermal properties, magnetic nanoparticles (MNPs) have comprehensive applications as the contrast and therapeutic agents in biomedical imaging and magnetic hyperthermia. The linear and nonlinear magnetoacoustic responses determined by the magnetic properties of MNPs have attracted more and more attention in biomedical engineering. By considering the relaxation time of MNPs, we derive the formulae of second harmonic magnetoacoustic responses (2H-MARs) for a cylindrical MNP solution model based on the mechanical oscillations of MNPs in magnetoacoustic tomography with magnetic induction (MAT-MI). It is proved that only the second harmonic magnetoacoustic oscillations can be generated by MNPs under an alternating magnetic excitation. The acoustic pressure of the 2H-MAR is proportional to the square of the magnetic field intensity and exhibits a linear increase with the concentration of MNPs. Numerical simulations of the 2H-MAR are confirmed by the experimental measurements for various magnetic field intensities and solution concentrations using a laser vibrometer. The favorable results demonstrate the feasibility of the harmonic measurements without the fundamental interference of the electromagnetic excitation, and suggest a new harmonic imaging strategy of MAT-MI for MNPs with enhanced spatial resolution and improved signal-to-noise ratio in biomedical applications.

关键词: magnetoacoustic tomography with magnetic induction, second harmonic magnetoacoustic responses, magnetic nanoparticles, magnetic force, mechanical oscillations

Abstract: Due to the unique magnetic, mechanical and thermal properties, magnetic nanoparticles (MNPs) have comprehensive applications as the contrast and therapeutic agents in biomedical imaging and magnetic hyperthermia. The linear and nonlinear magnetoacoustic responses determined by the magnetic properties of MNPs have attracted more and more attention in biomedical engineering. By considering the relaxation time of MNPs, we derive the formulae of second harmonic magnetoacoustic responses (2H-MARs) for a cylindrical MNP solution model based on the mechanical oscillations of MNPs in magnetoacoustic tomography with magnetic induction (MAT-MI). It is proved that only the second harmonic magnetoacoustic oscillations can be generated by MNPs under an alternating magnetic excitation. The acoustic pressure of the 2H-MAR is proportional to the square of the magnetic field intensity and exhibits a linear increase with the concentration of MNPs. Numerical simulations of the 2H-MAR are confirmed by the experimental measurements for various magnetic field intensities and solution concentrations using a laser vibrometer. The favorable results demonstrate the feasibility of the harmonic measurements without the fundamental interference of the electromagnetic excitation, and suggest a new harmonic imaging strategy of MAT-MI for MNPs with enhanced spatial resolution and improved signal-to-noise ratio in biomedical applications.

Key words: magnetoacoustic tomography with magnetic induction, second harmonic magnetoacoustic responses, magnetic nanoparticles, magnetic force, mechanical oscillations

中图分类号: (Acoustical measurement methods in biological systems and media)

43.80.Ev

72.55.+s (Magnetoacoustic effects)

郭各朴, 高雅, 李禹志, 马青玉, 屠娟, 章东. Second harmonic magnetoacoustic responses of magnetic nanoparticles in magnetoacoustic tomography with magnetic induction[J]. 中国物理B, 2020, 29(3): 34302-034302.

Gepu Guo(郭各朴), Ya Gao(高雅), Yuzhi Li(李禹志), Qingyu Ma(马青玉), Juan Tu(屠娟), Dong Zhang(章东). Second harmonic magnetoacoustic responses of magnetic nanoparticles in magnetoacoustic tomography with magnetic induction[J]. Chin. Phys. B, 2020, 29(3): 34302-034302.

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Second harmonic magnetoacoustic responses of magnetic nanoparticles in magnetoacoustic tomography with magnetic induction

Second harmonic magnetoacoustic responses of magnetic nanoparticles in magnetoacoustic tomography with magnetic induction

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