中国物理B ›› 2017, Vol. 26 ›› Issue (12): 128703-128703.doi: 10.1088/1674-1056/26/12/128703
所属专题: SPECIAL TOPIC — Soft matter and biological physics
• SPECIAL TOPIC—Soft matter and biological physics • 上一篇 下一篇
Xiang Li(李翔), Jing-Jing Zhong(钟金金), Xue-Juan Gao(高学娟), Yu-Ning Wu(吴宇宁), Jian-Wei Shuai(帅建伟), Hong Qi(祁宏)
Xiang Li(李翔)1,2, Jing-Jing Zhong(钟金金)1, Xue-Juan Gao(高学娟)1, Yu-Ning Wu(吴宇宁)1, Jian-Wei Shuai(帅建伟)1,2,3, Hong Qi(祁宏)4,5
摘要:
The biexponential distributions of open times are observed in various types of ion channels. In this paper, by discussing a simple channel model, we show that there are two different schemes to understand the biexponential distribution of open times. One scheme is mathematically strict based on generator matrix theory, while the other one has a clear physical explanation according to an approximation process with numerical simulation of Markovian channel dynamics. Our comparison results suggest that even for biologically complex channels, in addition to carrying out a stochastic simulation, the strict theoretical analysis should be considered to understand the multiple exponential distributions of open times.
中图分类号: (Ion channels)