中国物理B ›› 2011, Vol. 20 ›› Issue (2): 28701-028701.doi: 10.1088/1674-1056/20/2/028701

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A new level set model for cell image segmentation

侯凯1, 包尚联2, 马竟锋3, 陈纯3   

  1. (1)Beijing Healthway Technology Limited Company, Beijing 100084, China; (2)Beijing Key Lab of Medical Physics and Engineering, Peking University, Beijing 100871, China; Beijing Healthway Technology Limited Company, Beijing 100084, China; (3)College of Computer Science and Technology, Zhejiang University, Hangzhou 310027, China
  • 收稿日期:2010-08-23 修回日期:2010-09-21 出版日期:2011-02-15 发布日期:2011-02-15
  • 基金资助:
    Project supported by the National Basic Research Program of China (Grant No. 2011CB707701), the National Natural Science Foundation of China (Grant No. 60873124), the Joint Research Foundation of Beijing Education Committee (Grant No. JD100010607), the International Science and Technology Supporting Programme (Grant No. 2008BAH26B00), and the Zhejiang Service Robot Key Laboratory (Grant No. 2008E10004).

A new level set model for cell image segmentation

Ma Jing-Feng(马竟锋)a), Hou Kai(侯凯) c), Bao Shang-Lian(包尚联)b)c), and Chen Chun(陈纯)a)†   

  1. a College of Computer Science and Technology, Zhejiang University, Hangzhou 310027, China; b Beijing Key Lab of Medical Physics and Engineering, Peking University, Beijing 100871, China; c Beijing Healthway Technology Limited Company, Beijing 100084, China
  • Received:2010-08-23 Revised:2010-09-21 Online:2011-02-15 Published:2011-02-15
  • Supported by:
    Project supported by the National Basic Research Program of China (Grant No. 2011CB707701), the National Natural Science Foundation of China (Grant No. 60873124), the Joint Research Foundation of Beijing Education Committee (Grant No. JD100010607), the International Science and Technology Supporting Programme (Grant No. 2008BAH26B00), and the Zhejiang Service Robot Key Laboratory (Grant No. 2008E10004).

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摘要： In this paper we first determine three phases of cell images: background, cytoplasm and nucleolus according to the general physical characteristics of cell images, and then develop a variational model, based on these characteristics, to segment nucleolus and cytoplasm from their relatively complicated backgrounds. In the meantime, the preprocessing obtained information of cell images using the OTSU algorithm is used to initialize the level set function in the model, which can speed up the segmentation and present satisfactory results in cell image processing.

关键词: cell image segmentation, 3-phase, level set, OTSU algorithm

Abstract: In this paper we first determine three phases of cell images: background, cytoplasm and nucleolus according to the general physical characteristics of cell images, and then develop a variational model, based on these characteristics, to segment nucleolus and cytoplasm from their relatively complicated backgrounds. In the meantime, the preprocessing obtained information of cell images using the OTSU algorithm is used to initialize the level set function in the model, which can speed up the segmentation and present satisfactory results in cell image processing.

Key words: cell image segmentation, 3-phase, level set, OTSU algorithm

中图分类号:  (Segmentation)

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