中国物理B ›› 2009, Vol. 18 ›› Issue (3): 872-880.doi: 10.1088/1674-1056/18/3/005

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Spatiotemporal multiple coherence resonances and calcium waves in a coupled hepatocyte system

陆启韶1, 吕淑娟1, 郎秀锋1, 王宝华2   

  1. (1)School of Science, Beijing University of Aeronautics-Astronautics, Beijing 100191, China; (2)School of Science, Beijing University of Aeronautics-Astronautics, Beijing 100191, China;College of Mathematics Science, Heilongjiang University, Harbin 150080, China
  • 收稿日期:2008-07-19 修回日期:2008-08-29 出版日期:2009-03-20 发布日期:2009-03-20
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant Nos 10432010 and 10872014).

Spatiotemporal multiple coherence resonances and calcium waves in a coupled hepatocyte system

Wang Bao-Hua(王宝华)a)b), Lu Qi-Shao(陆启韶)a)†, Lü Shu-Juan(吕淑娟)a), and Lang Xiu-Feng(郎秀锋)a)   

  1. a School of Science, Beijing University of Aeronautics-Astronautics, Beijing 100191, China; b College of Mathematics Science, Heilongjiang University, Harbin 150080, China
  • Received:2008-07-19 Revised:2008-08-29 Online:2009-03-20 Published:2009-03-20
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant Nos 10432010 and 10872014).

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摘要： Spatiotemporal multiple coherence resonances for calcium activities induced by weak Gaussian white noise in coupled hepatocytes are studied. It is shown that bi-resonances in hepatocytes are induced by the interplay and competition between noise and coupling of cells, in other words, the cell in network can be excited either by noise or by its neighbour via gap junction which can transfer calcium ions between cells. Furthermore, the intercellular annular calcium waves induced by noise are observed, in which the wave length decreases with noise intensity augmenting but increases monotonically with coupling strength increasing. And for a fixed noise level, there is an optimal coupling strength that makes the coherence resonance reach maximum.

关键词: multiple resonance, coherence, intercellular calcium wave, noise

Abstract: Spatiotemporal multiple coherence resonances for calcium activities induced by weak Gaussian white noise in coupled hepatocytes are studied. It is shown that bi-resonances in hepatocytes are induced by the interplay and competition between noise and coupling of cells, in other words, the cell in network can be excited either by noise or by its neighbour via gap junction which can transfer calcium ions between cells. Furthermore, the intercellular annular calcium waves induced by noise are observed, in which the wave length decreases with noise intensity augmenting but increases monotonically with coupling strength increasing. And for a fixed noise level, there is an optimal coupling strength that makes the coherence resonance reach maximum.

Key words: multiple resonance, coherence, intercellular calcium wave, noise

中图分类号:  (Spatiotemporal pattern formation in cellular populations)

  • 87.18.Hf
87.18.-h (Biological complexity) 87.10.-e (General theory and mathematical aspects)