中国物理B ›› 2023, Vol. 32 ›› Issue (1): 14302-014302.doi: 10.1088/1674-1056/ac70ba

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Effects of adjacent bubble on spatiotemporal evolutions of mechanical stresses surrounding bubbles oscillating in tissues

Qing-Qin Zou(邹青钦), Shuang Lei(雷双), Zhang-Yong Li(李章勇), and Dui Qin(秦对)†   

  1. Department of Biomedical Engineering, School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China
  • 收稿日期:2022-03-31 修回日期:2022-04-25 接受日期:2022-05-18 出版日期:2022-12-08 发布日期:2022-12-27
  • 通讯作者: Dui Qin E-mail:duiqin@cqupt.edu.cn
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant No. 11904042), the Natural Science Foundation of Chongqing, China (Grant No. cstc2019jcyjmsxmX0534), and the Science and Technology Research Program of Chongqing Municipal Education Commission, China (Grant No. KJQN202000617).

Effects of adjacent bubble on spatiotemporal evolutions of mechanical stresses surrounding bubbles oscillating in tissues

Qing-Qin Zou(邹青钦), Shuang Lei(雷双), Zhang-Yong Li(李章勇), and Dui Qin(秦对)†   

  1. Department of Biomedical Engineering, School of Bioinformatics, Chongqing University of Posts and Telecommunications, Chongqing 400065, China
  • Received:2022-03-31 Revised:2022-04-25 Accepted:2022-05-18 Online:2022-12-08 Published:2022-12-27
  • Contact: Dui Qin E-mail:duiqin@cqupt.edu.cn
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant No. 11904042), the Natural Science Foundation of Chongqing, China (Grant No. cstc2019jcyjmsxmX0534), and the Science and Technology Research Program of Chongqing Municipal Education Commission, China (Grant No. KJQN202000617).

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摘要： The cavitation dynamics and mechanical stress in viscoelastic tissues, as the primary mechanisms of some ultrasound therapies, are extremely complex due to the interactions of cavitation bubble with adjacent bubbles and surrounding tissues. Therefore, the cavitation dynamics and resultant mechanical stress of two-interacting bubbles in the viscoelastic tissues are numerically investigated, especially focusing on the effects of the adjacent bubble. The results demonstrate that the mechanical stress is highly dependent on the bubble dynamics. The compressive stress and tensile stress are generated at the stage of bubble expansion and collapse stage, respectively. Furthermore, within the initial parameters examined in this paper, the effects of the adjacent bubble will distinctly suppress the radial expansion of the small bubble and consequently lead its associated stresses to decrease. Owing to the superimposition of two stress fields, the mechanical stresses surrounding the small bubble in the direction of the neighboring bubble are smaller than those in other directions. For two interacting cavitation bubbles, the suppression effects of the nearby bubble on both the cavitation dynamics and the stresses surrounding the small bubble increase as the ultrasound amplitude and the initial radius of the large bubble increase, whereas they decrease with the inter-bubble distance increasing. Moreover, increasing the tissue viscoelasticity will reduce the suppression effects of the nearby bubble, except in instances where the compressive stress and tensile stress first increase and then decrease with the tissue elasticity and viscosity increasing respectively. This study can provide a further understanding of the mechanisms of cavitation-associated mechanical damage to the adjacent tissues or cells.

关键词: cavitation dynamics, cavitation-induced mechanical stress, effects of the nearby bubble, viscoelastic tissues

Abstract: The cavitation dynamics and mechanical stress in viscoelastic tissues, as the primary mechanisms of some ultrasound therapies, are extremely complex due to the interactions of cavitation bubble with adjacent bubbles and surrounding tissues. Therefore, the cavitation dynamics and resultant mechanical stress of two-interacting bubbles in the viscoelastic tissues are numerically investigated, especially focusing on the effects of the adjacent bubble. The results demonstrate that the mechanical stress is highly dependent on the bubble dynamics. The compressive stress and tensile stress are generated at the stage of bubble expansion and collapse stage, respectively. Furthermore, within the initial parameters examined in this paper, the effects of the adjacent bubble will distinctly suppress the radial expansion of the small bubble and consequently lead its associated stresses to decrease. Owing to the superimposition of two stress fields, the mechanical stresses surrounding the small bubble in the direction of the neighboring bubble are smaller than those in other directions. For two interacting cavitation bubbles, the suppression effects of the nearby bubble on both the cavitation dynamics and the stresses surrounding the small bubble increase as the ultrasound amplitude and the initial radius of the large bubble increase, whereas they decrease with the inter-bubble distance increasing. Moreover, increasing the tissue viscoelasticity will reduce the suppression effects of the nearby bubble, except in instances where the compressive stress and tensile stress first increase and then decrease with the tissue elasticity and viscosity increasing respectively. This study can provide a further understanding of the mechanisms of cavitation-associated mechanical damage to the adjacent tissues or cells.

Key words: cavitation dynamics, cavitation-induced mechanical stress, effects of the nearby bubble, viscoelastic tissues

中图分类号:  (Ultrasonics, quantum acoustics, and physical effects of sound)

  • 43.35.+d
47.55.dd (Bubble dynamics) 87.50.Y- (Biological effects of acoustic and ultrasonic energy)