Determining the imaging plane of a retinal capillary layer in adaptive optical imaging

doi:10.1088/1674-1056/25/9/094219

中国物理B ›› 2016, Vol. 25 ›› Issue (9): 94219-094219.doi: 10.1088/1674-1056/25/9/094219

• SPECIAL TOPIC—Physical research in liquid crystal • 上一篇下一篇

Determining the imaging plane of a retinal capillary layer in adaptive optical imaging

Le-Bao Yang(杨乐宝), Li-Fa Hu(胡立发), Da-Yu Li(李大禹), Zhao-Liang Cao(曹召良), Quan-Quan Mu(穆全全), Ji Ma(马骥), Li Xuan(宣丽)

1. State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China;
3. Liquid Crystal Institute, Kent State University, Kent 44242, USA

收稿日期:2016-05-19 出版日期:2016-09-05 发布日期:2016-09-05
通讯作者: Li Xuan E-mail:xuanli1957@sina.com
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11174274, 11174279, 61205021, 11204299, 61475152, and 61405194).

Determining the imaging plane of a retinal capillary layer in adaptive optical imaging

Le-Bao Yang(杨乐宝)^1,2, Li-Fa Hu(胡立发)¹, Da-Yu Li(李大禹)¹, Zhao-Liang Cao(曹召良)¹, Quan-Quan Mu(穆全全)¹, Ji Ma(马骥)^1,3, Li Xuan(宣丽)¹

1. State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China;
3. Liquid Crystal Institute, Kent State University, Kent 44242, USA

Received:2016-05-19 Online:2016-09-05 Published:2016-09-05
Contact: Li Xuan E-mail:xuanli1957@sina.com
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11174274, 11174279, 61205021, 11204299, 61475152, and 61405194).

摘要/Abstract

摘要： Even in the early stage, endocrine metabolism disease may lead to micro aneurysms in retinal capillaries whose diameters are less than 10 μ. However, the fundus cameras used in clinic diagnosis can only obtain images of vessels larger than 20 μ in diameter. The human retina is a thin and multiple layer tissue, and the layer of capillaries less than 10 μ in diameter only exists in the inner nuclear layer. The layer thickness of capillaries less than 10 μ in diameter is about 40 μ and the distance range to rod&cone cell surface is tens of micrometers, which varies from person to person. Therefore, determining reasonable capillary layer (CL) position in different human eyes is very difficult. In this paper, we propose a method to determine the position of retinal CL based on the rod&cone cell layer. The public positions of CL are recognized with 15 subjects from 40 to 59 years old, and the imaging planes of CL are calculated by the effective focal length of the human eye. High resolution retinal capillary imaging results obtained from 17 subjects with a liquid crystal adaptive optics system (LCAOS) validate our method. All of the subjects' CLs have public positions from 127 μm to 147 μm from the rod&cone cell layer, which is influenced by the depth of focus.

关键词: liquid crystal device, adaptive optics, capillary layer position, retinal imaging

Abstract: Even in the early stage, endocrine metabolism disease may lead to micro aneurysms in retinal capillaries whose diameters are less than 10 μ. However, the fundus cameras used in clinic diagnosis can only obtain images of vessels larger than 20 μ in diameter. The human retina is a thin and multiple layer tissue, and the layer of capillaries less than 10 μ in diameter only exists in the inner nuclear layer. The layer thickness of capillaries less than 10 μ in diameter is about 40 μ and the distance range to rod&cone cell surface is tens of micrometers, which varies from person to person. Therefore, determining reasonable capillary layer (CL) position in different human eyes is very difficult. In this paper, we propose a method to determine the position of retinal CL based on the rod&cone cell layer. The public positions of CL are recognized with 15 subjects from 40 to 59 years old, and the imaging planes of CL are calculated by the effective focal length of the human eye. High resolution retinal capillary imaging results obtained from 17 subjects with a liquid crystal adaptive optics system (LCAOS) validate our method. All of the subjects' CLs have public positions from 127 μm to 147 μm from the rod&cone cell layer, which is influenced by the depth of focus.

Key words: liquid crystal device, adaptive optics, capillary layer position, retinal imaging

中图分类号: (Liquid crystals)

42.70.Df

42.68.Wt (Remote sensing; LIDAR and adaptive systems) 42.66.Lc (Vision: light detection, adaptation, and discrimination)

杨乐宝, 胡立发, 李大禹, 曹召良, 穆全全, 马骥, 宣丽. Determining the imaging plane of a retinal capillary layer in adaptive optical imaging[J]. 中国物理B, 2016, 25(9): 94219-094219.

Le-Bao Yang(杨乐宝), Li-Fa Hu(胡立发), Da-Yu Li(李大禹), Zhao-Liang Cao(曹召良), Quan-Quan Mu(穆全全), Ji Ma(马骥), Li Xuan(宣丽). Determining the imaging plane of a retinal capillary layer in adaptive optical imaging[J]. Chin. Phys. B, 2016, 25(9): 94219-094219.

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Determining the imaging plane of a retinal capillary layer in adaptive optical imaging

Determining the imaging plane of a retinal capillary layer in adaptive optical imaging

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