A new understanding of inert gas narcosis

doi:10.1088/1674-1056/25/1/013602

中国物理B ›› 2016, Vol. 25 ›› Issue (1): 13602-013602.doi: 10.1088/1674-1056/25/1/013602

所属专题： TOPICAL REVIEW — 8th IUPAP International Conference on Biological Physics

• TOPICAL REVIEW—8th IUPAP International Conference on Biological Physics • 上一篇下一篇

A new understanding of inert gas narcosis

Meng Zhang(张萌), Yi Gao(高嶷), Haiping Fang(方海平)

1. Division of Interfacial Water and Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;
2. School of Information Technology & Engineering, Jinzhong University, Jinzhong 030619, China

收稿日期:2015-05-23 修回日期:2015-11-30 出版日期:2016-01-05 发布日期:2016-01-05
通讯作者: Yi Gao, Haiping Fang E-mail:gaoyi@sinap.ac.cn;fanghaiping@sinap.ac.cn
基金资助:
Project supported by the Supercomputing Center of Chinese Academy of Sciences in Beijing, China, the Shanghai Supercomputer Center, China, the National Natural Science Foundation of China (Grant Nos. 21273268, 11290164, and 11175230), the Startup Funding from Shanghai Institute of Applied Physics, Chinese Academy of Sciences (Grant No. Y290011011), “Hundred People Project” from Chinese Academy of Sciences, and “Pu-jiang Rencai Project” from Science and Technology Commission of Shanghai Municipality, China (Grant No. 13PJ1410400).

A new understanding of inert gas narcosis

Meng Zhang(张萌)^1,2, Yi Gao(高嶷)¹, Haiping Fang(方海平)¹

1. Division of Interfacial Water and Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;
2. School of Information Technology & Engineering, Jinzhong University, Jinzhong 030619, China

Received:2015-05-23 Revised:2015-11-30 Online:2016-01-05 Published:2016-01-05
Contact: Yi Gao, Haiping Fang E-mail:gaoyi@sinap.ac.cn;fanghaiping@sinap.ac.cn
Supported by:
Project supported by the Supercomputing Center of Chinese Academy of Sciences in Beijing, China, the Shanghai Supercomputer Center, China, the National Natural Science Foundation of China (Grant Nos. 21273268, 11290164, and 11175230), the Startup Funding from Shanghai Institute of Applied Physics, Chinese Academy of Sciences (Grant No. Y290011011), “Hundred People Project” from Chinese Academy of Sciences, and “Pu-jiang Rencai Project” from Science and Technology Commission of Shanghai Municipality, China (Grant No. 13PJ1410400).

摘要/Abstract

摘要：

Anesthetics are extremely important in modern surgery to greatly reduce the patient's pain. The understanding of anesthesia at molecular level is the preliminary step for the application of anesthetics in clinic safely and effectively. Inert gases, with low chemical activity, have been found to cause anesthesia for centuries, but the mechanism is unclear yet. In this review, we first summarize the progress of theories about general anesthesia, especially for inert gas narcosis, and then propose a new hypothesis that the aggregated rather than the dispersed inert gas molecules are the key to trigger the narcosis to explain the steep dose-response relationship of anesthesia.

关键词: cluster, inert gas, anesthesia, narcotic potency

Abstract:

Key words: cluster, inert gas, anesthesia, narcotic potency

中图分类号: (Atomic and molecular clusters)

36.40.-c

82.20.Wt (Computational modeling; simulation) 87.15.A- (Theory, modeling, and computer simulation) 87.50.cf (Biophysical mechanisms of interaction)

张萌, 高嶷, 方海平. A new understanding of inert gas narcosis[J]. 中国物理B, 2016, 25(1): 13602-013602.

Meng Zhang(张萌), Yi Gao(高嶷), Haiping Fang(方海平). A new understanding of inert gas narcosis[J]. Chin. Phys. B, 2016, 25(1): 13602-013602.

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A new understanding of inert gas narcosis

A new understanding of inert gas narcosis

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