中国物理B ›› 2015, Vol. 24 ›› Issue (12): 120501-120501.doi: 10.1088/1674-1056/24/12/120501
• SPECIAL TOPIC—8th IUPAP International Conference on Biological Physics • 上一篇 下一篇
黄艳东, 李翔, 帅建伟
Huang Yan-Dong (黄艳东), Li Xiang (李翔), Shuai Jian-Wei (帅建伟)
摘要: The Langevin approach has been applied to model the random open and closing dynamics of ion channels. It has long been known that the gate-based Langevin approach is not sufficiently accurate to reproduce the statistics of stochastic channel dynamics in Hodgkin-Huxley neurons. Here, we introduce a modified gate-based Langevin approach with rescaled noise strength to simulate stochastic channel dynamics. The rescaled independent gate and identical gate Langevin approaches improve the statistical results for the mean membrane voltage, inter-spike interval, and spike amplitude.
中图分类号: (Stochastic analysis methods)