Multiscale structural complexity analysis of neuronal activity in suprachiasmatic nucleus: Insights from tetrodotoxin-induced disruptions

doi:10.1088/1674-1056/adaccd

中国物理B ›› 2025, Vol. 34 ›› Issue (4): 48701-048701.doi: 10.1088/1674-1056/adaccd

Multiscale structural complexity analysis of neuronal activity in suprachiasmatic nucleus: Insights from tetrodotoxin-induced disruptions

Ping Wang(王萍)¹, Changgui Gu(顾长贵)^2,†, and Huijie Yang(杨会杰)²

1 School of Science, Jiangsu University of Science and Technology, Zhenjiang 212100, China;
2 Business School, University of Shanghai for Science and Technology, Shanghai 200433, China

收稿日期:2024-11-13 修回日期:2024-12-18 接受日期:2025-01-22 出版日期:2025-04-15 发布日期:2025-04-15
通讯作者: Changgui Gu E-mail:gu_changgui@163.com
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 12275179, 11875042, and 12150410309) and the Natural Science Foundation of Shanghai (Grant No. 21ZR1443900).

Multiscale structural complexity analysis of neuronal activity in suprachiasmatic nucleus: Insights from tetrodotoxin-induced disruptions

Ping Wang(王萍)¹, Changgui Gu(顾长贵)^2,†, and Huijie Yang(杨会杰)²

1 School of Science, Jiangsu University of Science and Technology, Zhenjiang 212100, China;
2 Business School, University of Shanghai for Science and Technology, Shanghai 200433, China

Received:2024-11-13 Revised:2024-12-18 Accepted:2025-01-22 Online:2025-04-15 Published:2025-04-15
Contact: Changgui Gu E-mail:gu_changgui@163.com
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 12275179, 11875042, and 12150410309) and the Natural Science Foundation of Shanghai (Grant No. 21ZR1443900).

摘要/Abstract

摘要： The suprachiasmatic nucleus in the hypothalamus is the master circadian clock in mammals, coordinating physiological processes with the 24-hour day-night cycle. Comprising various cell types, the suprachiasmatic nucleus (SCN) integrates environmental signals to maintain complex and robust circadian rhythms. Understanding the complexity and synchrony within SCN neurons is essential for effective circadian clock function. Synchrony involves coordinated neuronal firing for robust rhythms, while complexity reflects diverse activity patterns and interactions, indicating adaptability. Interestingly, the SCN retains circadian rhythms in vitro, demonstrating intrinsic rhythmicity. This study introduces the multiscale structural complexity method to analyze changes in SCN neuronal activity and complexity at macro and micro levels, based on Bagrov et al.'s approach. By examining structural complexity and local complexities across scales, we aim to understand how tetrodotoxin, a neurotoxin that inhibits action potentials, affects SCN neurons. Our method captures critical scales in neuronal interactions that traditional methods may overlook. Validation with the Goodwin model confirms the reliability of our observations. By integrating experimental data with theoretical models, this study provides new insights into the effects of tetrodotoxin (TTX) on neuronal complexities, contributing to the understanding of circadian rhythms.

关键词: suprachiasmatic nucleus, circadian rhythm, complexity, synchrony, multiscale structural complexity

Abstract: The suprachiasmatic nucleus in the hypothalamus is the master circadian clock in mammals, coordinating physiological processes with the 24-hour day-night cycle. Comprising various cell types, the suprachiasmatic nucleus (SCN) integrates environmental signals to maintain complex and robust circadian rhythms. Understanding the complexity and synchrony within SCN neurons is essential for effective circadian clock function. Synchrony involves coordinated neuronal firing for robust rhythms, while complexity reflects diverse activity patterns and interactions, indicating adaptability. Interestingly, the SCN retains circadian rhythms in vitro, demonstrating intrinsic rhythmicity. This study introduces the multiscale structural complexity method to analyze changes in SCN neuronal activity and complexity at macro and micro levels, based on Bagrov et al.'s approach. By examining structural complexity and local complexities across scales, we aim to understand how tetrodotoxin, a neurotoxin that inhibits action potentials, affects SCN neurons. Our method captures critical scales in neuronal interactions that traditional methods may overlook. Validation with the Goodwin model confirms the reliability of our observations. By integrating experimental data with theoretical models, this study provides new insights into the effects of tetrodotoxin (TTX) on neuronal complexities, contributing to the understanding of circadian rhythms.

Key words: suprachiasmatic nucleus, circadian rhythm, complexity, synchrony, multiscale structural complexity

中图分类号: (Circadian rhythms)

87.18.Yt

05.45.Xt (Synchronization; coupled oscillators)

Ping Wang(王萍), Changgui Gu(顾长贵), and Huijie Yang(杨会杰). Multiscale structural complexity analysis of neuronal activity in suprachiasmatic nucleus: Insights from tetrodotoxin-induced disruptions[J]. 中国物理B, 2025, 34(4): 48701-048701.

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Multiscale structural complexity analysis of neuronal activity in suprachiasmatic nucleus: Insights from tetrodotoxin-induced disruptions

Multiscale structural complexity analysis of neuronal activity in suprachiasmatic nucleus: Insights from tetrodotoxin-induced disruptions

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