中国物理B ›› 2022, Vol. 31 ›› Issue (11): 118701-118701.doi: 10.1088/1674-1056/ac80ae

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Pattern transition and regulation in a subthalamopallidal network under electromagnetic effect

Zilu Cao(曹子露)1,3, Lin Du(都琳)1,3,†, Honghui Zhang(张红慧)1,3,‡, Yuzhi Zhao(赵玉枝)1,3, Zhuan Shen(申转)1,3, and Zichen Deng(邓子辰)2,3   

  1. 1 School of Mathematics and Statistics, Northwestern Polytechnical University, Xi'an 710129, China;
    2 School of Aeronautics, Northwestern Polytechnical University, Xi'an 710072, China;
    3 MIIT Key Laboratory of Dynamics and Control of Complex Systems, Xi'an 710129, China
  • 收稿日期:2022-04-04 修回日期:2022-07-04 接受日期:2022-07-13 出版日期:2022-10-17 发布日期:2022-10-28
  • 通讯作者: Lin Du, Honghui Zhang E-mail:lindu@nwpu.edu.cn;haozhucy@nwpu.edu.cn
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant Nos. 11972292, 12172291, and 12072265) and the 111 Project (Grant No. BP0719007). The authors wish to acknowledge Ms. Luyao Yan, Mr. Lianghui Qu, and Mr. Haiwei Hu for their help in interpreting the significance of the results of this study.

Pattern transition and regulation in a subthalamopallidal network under electromagnetic effect

Zilu Cao(曹子露)1,3, Lin Du(都琳)1,3,†, Honghui Zhang(张红慧)1,3,‡, Yuzhi Zhao(赵玉枝)1,3, Zhuan Shen(申转)1,3, and Zichen Deng(邓子辰)2,3   

  1. 1 School of Mathematics and Statistics, Northwestern Polytechnical University, Xi'an 710129, China;
    2 School of Aeronautics, Northwestern Polytechnical University, Xi'an 710072, China;
    3 MIIT Key Laboratory of Dynamics and Control of Complex Systems, Xi'an 710129, China
  • Received:2022-04-04 Revised:2022-07-04 Accepted:2022-07-13 Online:2022-10-17 Published:2022-10-28
  • Contact: Lin Du, Honghui Zhang E-mail:lindu@nwpu.edu.cn;haozhucy@nwpu.edu.cn
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant Nos. 11972292, 12172291, and 12072265) and the 111 Project (Grant No. BP0719007). The authors wish to acknowledge Ms. Luyao Yan, Mr. Lianghui Qu, and Mr. Haiwei Hu for their help in interpreting the significance of the results of this study.

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摘要： Although the significant roles of magnetic induction and electromagnetic radiation in the neural system have been widely studied, their influence on Parkinson's disease (PD) has yet to be well explored. By virtue of the magnetic flux variable, this paper studies the transition of firing patterns induced by magnetic induction and the regulation effect of external magnetic radiation on the firing activities of the subthalamopallidal network in basal ganglia. We find: (i) The network reproduces five typical waveforms corresponding to the severity of symptoms: weak cluster, episodic, continuous cluster, episodic, and continuous wave. (ii) Magnetic induction is a double-edged sword for the treatment of PD. Although the increase of magnetic coefficient may lead the physiological firing activity to transfer to pathological firing activity, it also can regulate the pathological intensity firing activity with excessive β-band power transferring to the physiological firing pattern with weak β-band power. (iii) External magnetic radiation could inhibit continuous tremulous firing and β-band power of subthalamic nucleus (STN), which means the severity of symptoms weakened. Especially, the bi-parameter plane of the regulation region shows that a short pulse period of magnetic radiation and a medium level of pulse percentage can well regulate pathological oscillation. This work helps to understand the firing activity of the subthalamopallidal network under electromagnetic effect. It may also provide insights into the mechanisms behind the electromagnetic therapy of PD-related firing activity.

关键词: subthalamopallidal network, magnetic induction and radiation, pattern transition, regulation of pathological oscillation

Abstract: Although the significant roles of magnetic induction and electromagnetic radiation in the neural system have been widely studied, their influence on Parkinson's disease (PD) has yet to be well explored. By virtue of the magnetic flux variable, this paper studies the transition of firing patterns induced by magnetic induction and the regulation effect of external magnetic radiation on the firing activities of the subthalamopallidal network in basal ganglia. We find: (i) The network reproduces five typical waveforms corresponding to the severity of symptoms: weak cluster, episodic, continuous cluster, episodic, and continuous wave. (ii) Magnetic induction is a double-edged sword for the treatment of PD. Although the increase of magnetic coefficient may lead the physiological firing activity to transfer to pathological firing activity, it also can regulate the pathological intensity firing activity with excessive β-band power transferring to the physiological firing pattern with weak β-band power. (iii) External magnetic radiation could inhibit continuous tremulous firing and β-band power of subthalamic nucleus (STN), which means the severity of symptoms weakened. Especially, the bi-parameter plane of the regulation region shows that a short pulse period of magnetic radiation and a medium level of pulse percentage can well regulate pathological oscillation. This work helps to understand the firing activity of the subthalamopallidal network under electromagnetic effect. It may also provide insights into the mechanisms behind the electromagnetic therapy of PD-related firing activity.

Key words: subthalamopallidal network, magnetic induction and radiation, pattern transition, regulation of pathological oscillation

中图分类号:  (Electrodynamics in the nervous system)

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87.19.ll (Models of single neurons and networks) 87.19.lj (Neuronal network dynamics)