Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia

doi:10.1088/1674-1056/ac744c

中国物理B ›› 2023, Vol. 32 ›› Issue (3): 34304-034304.doi: 10.1088/1674-1056/ac744c

Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia

Yundong Tang(汤云东)^1,†, Jian Zou(邹建)¹, Rodolfo C.C. Flesch², and Tao Jin(金涛)³

1 College of Physics and Information Engineering, Fuzhou University, Fuzhou 350116, China;
2 Departamento de Automação e Sistemas, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil;
3 College of Electrical Engineering and Automation, Fuzhou University, Fuzhou 350108, China

收稿日期:2022-03-07 修回日期:2022-05-10 接受日期:2022-05-29 出版日期:2023-02-14 发布日期:2023-02-21
通讯作者: Yundong Tang E-mail:tangyundong@fzu.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant No. 62071124), the Natural Science Foundation of Fujian Province, China (Grant No. 2020J01464), the Education Department of Fujian Province, China (Grant No. JAT190013), and the Conselho Nacional de Desenvolvimento Cientifico e Tecnoloico (BR) (CNPq) (Grant No. 309244/2018-8).

Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia

Yundong Tang(汤云东)^1,†, Jian Zou(邹建)¹, Rodolfo C.C. Flesch², and Tao Jin(金涛)³

1 College of Physics and Information Engineering, Fuzhou University, Fuzhou 350116, China;
2 Departamento de Automação e Sistemas, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil;
3 College of Electrical Engineering and Automation, Fuzhou University, Fuzhou 350108, China

Received:2022-03-07 Revised:2022-05-10 Accepted:2022-05-29 Online:2023-02-14 Published:2023-02-21
Contact: Yundong Tang E-mail:tangyundong@fzu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant No. 62071124), the Natural Science Foundation of Fujian Province, China (Grant No. 2020J01464), the Education Department of Fujian Province, China (Grant No. JAT190013), and the Conselho Nacional de Desenvolvimento Cientifico e Tecnoloico (BR) (CNPq) (Grant No. 309244/2018-8).

摘要/Abstract

摘要： Thermal damage of malignant tissue is generally determined not only by the characteristics of bio-tissues and nanoparticles but also the nanofluid concentration distributions due to different injection methods during magnetic hyperthermia. The latter has more advantages in improving the therapeutic effect with respect to the former since it is a determining factor for the uniformity of nanofluid concentration distribution inside the tumor region. This study investigates the effect of bio-tissue deformation due to intratumoral injection on the thermal damage behavior and treatment temperature distribution during magnetic hyperthermia, in which both the bio-tissue deformation due to nanofluid injection and the mass diffusion after injection behavior are taken into consideration. The nanofluid flow behavior is illustrated by two different theoretical models in this study, which are Navier-Stokes equation inside syringe needle and modified Darcy's law inside bio-tissue. The diffusion behavior after nanofluid injection is expressed by a modified convection-diffusion equation. A proposed three-dimensional liver model based on the angiographic data is set to be the research object in this study, in which all bio-tissues are assumed to be deformable porous media. Simulation results demonstrate that the injection point for syringe needle can generally achieve the maximum value in the tissue pressure, deformation degree, and interstitial flow velocity during the injection process, all of which then drop sharply with the distance away from the injection center. In addition to the bio-tissue deformation due to injection behavior, the treatment temperature is also highly relevant to determine both the diffusion duration and blood perfusion rate due to the thermal damage during the therapy.

关键词: tissue deformation, thermal apoptosis analysis, heat transfer, mass transfer

Abstract: Thermal damage of malignant tissue is generally determined not only by the characteristics of bio-tissues and nanoparticles but also the nanofluid concentration distributions due to different injection methods during magnetic hyperthermia. The latter has more advantages in improving the therapeutic effect with respect to the former since it is a determining factor for the uniformity of nanofluid concentration distribution inside the tumor region. This study investigates the effect of bio-tissue deformation due to intratumoral injection on the thermal damage behavior and treatment temperature distribution during magnetic hyperthermia, in which both the bio-tissue deformation due to nanofluid injection and the mass diffusion after injection behavior are taken into consideration. The nanofluid flow behavior is illustrated by two different theoretical models in this study, which are Navier-Stokes equation inside syringe needle and modified Darcy's law inside bio-tissue. The diffusion behavior after nanofluid injection is expressed by a modified convection-diffusion equation. A proposed three-dimensional liver model based on the angiographic data is set to be the research object in this study, in which all bio-tissues are assumed to be deformable porous media. Simulation results demonstrate that the injection point for syringe needle can generally achieve the maximum value in the tissue pressure, deformation degree, and interstitial flow velocity during the injection process, all of which then drop sharply with the distance away from the injection center. In addition to the bio-tissue deformation due to injection behavior, the treatment temperature is also highly relevant to determine both the diffusion duration and blood perfusion rate due to the thermal damage during the therapy.

Key words: tissue deformation, thermal apoptosis analysis, heat transfer, mass transfer

中图分类号: (Heat conduction)

44.10.+i

44.05.+e (Analytical and numerical techniques) 87.85.J- (Biomaterials)

Yundong Tang(汤云东), Jian Zou(邹建), Rodolfo C.C. Flesch, and Tao Jin(金涛). Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia[J]. 中国物理B, 2023, 32(3): 34304-034304.

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Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia

Effect of bio-tissue deformation behavior due to intratumoral injection on magnetic hyperthermia

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