Sensitivity enhancement of WS2-coated SPR-based optical fiber biosensor for detecting glucose concentration

doi:10.1088/1674-1056/aba601

中国物理B ›› 2020, Vol. 29 ›› Issue (11): 110701-.doi: 10.1088/1674-1056/aba601

Yun Cai(蔡云)¹^,⁴, Wei Li(李卫)¹^,²^,³^,⁴^,†(), Ye Feng(冯烨)¹^,⁴, Jian-Sheng Zhao(赵建胜)¹^,⁴, Gang Bai(白刚)¹^,⁴, Jie Xu(许杰)¹^,⁴, Jin-Ze Li(李金泽)¹^,⁴

收稿日期:2020-04-17 修回日期:2020-07-08 接受日期:2020-07-15 出版日期:2020-11-05 发布日期:2020-11-03

Sensitivity enhancement of WS₂-coated SPR-based optical fiber biosensor for detecting glucose concentration

Yun Cai(蔡云)^1,4, Wei Li(李卫)^{1,2,3,4, †}, Ye Feng(冯烨)^1,4, Jian-Sheng Zhao(赵建胜)^1,4, Gang Bai(白刚)^1,4, Jie Xu(许杰)^1,4, and Jin-Ze Li(李金泽)^1,4$

1 College of Electronic and Optical Engineering & College of Microelectronics, Nanjing University of Posts and Telecommunications, Nanjing 210023, China
2 State Key Laboratory of Millimeter Waves, Southeast University, Nanjing 210093, China
3 State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510641, China
4 Research Center of Optical Communications Engineering & Technology, Nanjing 210023, China

Received:2020-04-17 Revised:2020-07-08 Accepted:2020-07-15 Online:2020-11-05 Published:2020-11-03
Contact: ^†Corresponding author. E-mail: Liw@njupt.edu.cn
Supported by:
the Natural Science Foundation of Jiangsu Province, China (Grant No. BK20171442), the China Postdoctoral Science Foundation (Grant No. 2018T110480), the Open Foundation of State Key Laboratory of Millimeter Waves, China (Grant No. K202003), the Open Foundation of State Key Laboratory of Luminescent Materials and Devices, China (Grant No. 2020-skllmd-03), and the Fund from the Research Center of Optical Communications Engineering & Technology, Jiangsu Province, China (Grant No. ZXF201904).

摘要/Abstract

Abstract:

In this paper, we propose a theoretical model of the surface plasmon resonance-based optical fiber biosensor for detecting glucose concentration. The Au/ZnO/WS₂ multilayer film is coated around optical fiber. Compared with the conventional surface plasmon resonance sensor, WS₂ material can increase the sensitivity of the biosensor. The absorption capacity of WS₂ is used to load glucose oxidase by forming a sensitive area to recognize glucose. Refractive index of the solution is calculated and then the concentration of the glucose can be obtained by the correspondence between refractive index and glucose concentration. The highest sensitivity of the SPR biosensor with a structure of 40-nm Au/5-nm ZnO/14 layers of WS₂ is 4310 nm/RIU. The proposed WS₂-based SPR fiber biosensor has a unique effect on the detection of glucose concentration. It is expected to have potential applications in future medical blood glucose concentration detection.

Key words: surface plasmon resonance, optical fiber, biosensor, glucose

Yun Cai(蔡云), Wei Li(李卫), Ye Feng(冯烨), Jian-Sheng Zhao(赵建胜), Gang Bai(白刚), Jie Xu(许杰), Jin-Ze Li(李金泽). [J]. 中国物理B, 2020, 29(11): 110701-.

Yun Cai(蔡云), Wei Li(李卫), Ye Feng(冯烨), Jian-Sheng Zhao(赵建胜), Gang Bai(白刚), Jie Xu(许杰), and Jin-Ze Li(李金泽)$. Sensitivity enhancement of WS₂-coated SPR-based optical fiber biosensor for detecting glucose concentration[J]. Chin. Phys. B, 2020, 29(11): 110701-.

图/表 10

参考文献 41

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Thickness of ZnO layer/nm	Sensitivity/(nm/RIU) Number of WS₂ layer
Thickness of ZnO layer/nm	2	4	6	8	10	12	14	16	18
5	3750	3870	3980	4100	4180	4230	4310	4310	4290
10	3680	3710	3760	3760	3740	3680	3640	3600	3500
15	3560	3540	3490	3450	3340	3230	3150	3090	2970
20	3410	3340	3250	3160	3000	2860	2780	2720	2590

Structure	RI range	Sensitivity/(nm/RIU)	Reference
Ag/graphene	1.46–1.49	300	[40]
Au/ZnO	1.30–1.37	3161	[33]
Au/TiO₂	1.333–1.403	1015.15	[41]
Au/WS₂	1.333–1.360	2459.3	[30]
Au/ZnO/WS₂	1.33–1.37	4310	this work

Glucose	Refraction	Resonance wavelength/nm
concentration/(g/l)	index/(RIU)	Au/ZnO	Au/ZnO/WS₂
	1.33	603	1047
65	1.34	631	1080
149	1.35	664	1119
233	1.36	703	1165
317	1.37	750	1220

Sensitivity enhancement of WS₂-coated SPR-based optical fiber biosensor for detecting glucose concentration

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