Mechanochemical model for myosin II dimer that can explain the spontaneous oscillatory contraction of muscle

doi:10.1088/1674-1056/27/11/118702

中国物理B ›› 2018, Vol. 27 ›› Issue (11): 118702-118702.doi: 10.1088/1674-1056/27/11/118702

• INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇下一篇

Mechanochemical model for myosin II dimer that can explain the spontaneous oscillatory contraction of muscle

Wei Sun(孙伟), Xiao-Yang Zhao(赵晓阳), Jun-Ping Zhang(张俊萍), Tala(塔拉), Wei-Sheng Guo(郭维生)

1 School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China;
2 Department of Resource Engineering, Ordos Vocational College, Ordos 017000, China;
3 Department of Statistics and Mathematics, Inner Mongolia University of Finance and Economics, Hohhot 010070, China;
4 Inner Mongolia Vocational College of Chemical Engineering, Hohhot 010070, China

收稿日期:2018-06-15 修回日期:2018-09-03 出版日期:2018-11-05 发布日期:2018-11-05
通讯作者: Wei-Sheng Guo E-mail:pygws@imu.edu.cn
基金资助:
Project supported by Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region, China (Grant Nos. NJZY16493 and NJZC17458).

Mechanochemical model for myosin II dimer that can explain the spontaneous oscillatory contraction of muscle

Wei Sun(孙伟)^1,2, Xiao-Yang Zhao(赵晓阳)^3,4, Jun-Ping Zhang(张俊萍)¹, Tala(塔拉)¹, Wei-Sheng Guo(郭维生)¹

1 School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China;
2 Department of Resource Engineering, Ordos Vocational College, Ordos 017000, China;
3 Department of Statistics and Mathematics, Inner Mongolia University of Finance and Economics, Hohhot 010070, China;
4 Inner Mongolia Vocational College of Chemical Engineering, Hohhot 010070, China

Received:2018-06-15 Revised:2018-09-03 Online:2018-11-05 Published:2018-11-05
Contact: Wei-Sheng Guo E-mail:pygws@imu.edu.cn
Supported by:
Project supported by Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region, China (Grant Nos. NJZY16493 and NJZC17458).

摘要/Abstract

摘要：

The spontaneous oscillatory contraction (SPOC) of myofibrils is the essential property inherent to the contractile system of muscle. Muscle contraction results from cyclic interactions between actin filament and myosin Ⅱ which is a dimeric motor protein with two heads. Taking the two heads of myosin Ⅱ as an indivisible element and considering the effects of cooperative behavior between the two heads on rate constants in the mechanochemical cycle, the present work proposes the tenstate mechanochemical cycle model for myosin Ⅱ dimer. The simulations of this model show that the proportion of myosin Ⅱ in different states periodically changes with time, which results in the sustained oscillations of contractive tension, and serves as the primary factor for SPOC. The good fit of this model to experimental results suggests that the cooperative interaction between the two heads of myosin Ⅱ dimer may be one of the underlying mechanisms for muscle contraction.

关键词: muscle contraction, spontaneous oscillatory contraction (SPOC), mechanochemical cycle, cooperative behavior

Abstract:

Key words: muscle contraction, spontaneous oscillatory contraction (SPOC), mechanochemical cycle, cooperative behavior

中图分类号: (Reactions and kinetics)

87.15.R-

87.15.A- (Theory, modeling, and computer simulation) 82.39.-k (Chemical kinetics in biological systems)

孙伟, 赵晓阳, 张俊萍, 塔拉, 郭维生. Mechanochemical model for myosin II dimer that can explain the spontaneous oscillatory contraction of muscle[J]. 中国物理B, 2018, 27(11): 118702-118702.

Wei Sun(孙伟), Xiao-Yang Zhao(赵晓阳), Jun-Ping Zhang(张俊萍), Tala(塔拉), Wei-Sheng Guo(郭维生). Mechanochemical model for myosin II dimer that can explain the spontaneous oscillatory contraction of muscle[J]. Chin. Phys. B, 2018, 27(11): 118702-118702.

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Mechanochemical model for myosin II dimer that can explain the spontaneous oscillatory contraction of muscle

Mechanochemical model for myosin II dimer that can explain the spontaneous oscillatory contraction of muscle

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