中国物理B ›› 2016, Vol. 25 ›› Issue (6): 60702-060702.doi: 10.1088/1674-1056/25/6/060702

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Spectroscopic measurements and terahertz imaging of the cornea using a rapid scanning terahertz time domain spectrometer

Wen-Quan Liu(刘文权), Yuan-Fu Lu(鲁远甫), Guo-Hua Jiao(焦国华), Xian-Feng Chen(陈险峰), Zhi-Sheng Zhou(周志盛), Rong-Bin She(佘荣斌), Jin-Ying Li(李金瑛), Si-Hai Chen(陈四海), Yu-Ming Dong (董玉明), Jian-Cheng Lü(吕建成)   

  1. 1 Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;
    2 Biomedical Engineering Laboratory for Photoelectric Sensing Technology, Shenzhen 518055, China;
    3 Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen 518055, China;
    4 The Chinese University of Hong Kong, Shatin, Hong Kong, China;
    5 School of Electronic Engineering, Bangor University, Bangor, Gwynedd LL57 1UT, UK;
    6 Department of Ophthalmology, Peking University Shenzhen Hospital, Shenzhen 518036, China
  • 收稿日期:2015-12-17 修回日期:2016-03-22 出版日期:2016-06-05 发布日期:2016-06-05
  • 通讯作者: Yuan-Fu Lu E-mail:yf.lu@siat.ac.cn
  • 基金资助:

    Project supported by the National Natural Science Foundation of China (Grant No. 61205101), the Shenzhen Municipal Research Foundation, China (Grant Nos. GJHZ201404171134305 and JCYJ20140417113130693), and the Marie Curie Actions-International Research Staff Exchange Scheme (IRSES) (Grant No. FP7 PIRSES-2013-612267).

Spectroscopic measurements and terahertz imaging of the cornea using a rapid scanning terahertz time domain spectrometer

Wen-Quan Liu(刘文权)1,2,3,4, Yuan-Fu Lu(鲁远甫)1,2,4, Guo-Hua Jiao(焦国华)1,2,4, Xian-Feng Chen(陈险峰)5, Zhi-Sheng Zhou(周志盛)1,2,4, Rong-Bin She(佘荣斌)1,2,4, Jin-Ying Li(李金瑛)6, Si-Hai Chen(陈四海)1,2,4, Yu-Ming Dong (董玉明)1,2,4, Jian-Cheng Lü(吕建成)1,2,4   

  1. 1 Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China;
    2 Biomedical Engineering Laboratory for Photoelectric Sensing Technology, Shenzhen 518055, China;
    3 Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen 518055, China;
    4 The Chinese University of Hong Kong, Shatin, Hong Kong, China;
    5 School of Electronic Engineering, Bangor University, Bangor, Gwynedd LL57 1UT, UK;
    6 Department of Ophthalmology, Peking University Shenzhen Hospital, Shenzhen 518036, China
  • Received:2015-12-17 Revised:2016-03-22 Online:2016-06-05 Published:2016-06-05
  • Contact: Yuan-Fu Lu E-mail:yf.lu@siat.ac.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Grant No. 61205101), the Shenzhen Municipal Research Foundation, China (Grant Nos. GJHZ201404171134305 and JCYJ20140417113130693), and the Marie Curie Actions-International Research Staff Exchange Scheme (IRSES) (Grant No. FP7 PIRSES-2013-612267).

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摘要：

Spectroscopic measurements and terahertz imaging of the cornea are carried out by using a rapid scanning terahertz time domain spectroscopy (THz-TDS) system. A voice coil motor stage based optical delay line (VCM-ODL) is developed to provide a rather simple and robust structure with both the high scanning speed and the large delay length. The developed system is used for THz spectroscopic measurements and imaging of the corneal tissue with different amounts of water content, and the measurement results show the consistence with the reported results, in which the measurement time using VCM-ODL is a factor of 360 shorter than the traditional motorized optical delay line (MDL). With reducing the water content a monotonic decrease of the complex permittivity of the cornea is observed. The two-term Debye relaxation model is employed to explain our experimental results, revealing that the fast relaxation time of a dehydrated cornea is much larger than that of a hydrated cornea and its dielectric behavior can be affected by the presence of the biological macromolecules. These results demonstrate that our THz spectrometer may be a promising candidate for tissue hydration sensing and practical application of THz technology.

关键词: terahertz, rapid scanning terahertz time domain spectrometer, tissue diagnostics, terahertz imaging

Abstract:

Spectroscopic measurements and terahertz imaging of the cornea are carried out by using a rapid scanning terahertz time domain spectroscopy (THz-TDS) system. A voice coil motor stage based optical delay line (VCM-ODL) is developed to provide a rather simple and robust structure with both the high scanning speed and the large delay length. The developed system is used for THz spectroscopic measurements and imaging of the corneal tissue with different amounts of water content, and the measurement results show the consistence with the reported results, in which the measurement time using VCM-ODL is a factor of 360 shorter than the traditional motorized optical delay line (MDL). With reducing the water content a monotonic decrease of the complex permittivity of the cornea is observed. The two-term Debye relaxation model is employed to explain our experimental results, revealing that the fast relaxation time of a dehydrated cornea is much larger than that of a hydrated cornea and its dielectric behavior can be affected by the presence of the biological macromolecules. These results demonstrate that our THz spectrometer may be a promising candidate for tissue hydration sensing and practical application of THz technology.

Key words: terahertz, rapid scanning terahertz time domain spectrometer, tissue diagnostics, terahertz imaging

中图分类号:  (Submillimeter wave, microwave and radiowave spectrometers; magnetic resonance spectrometers, auxiliary equipment, and techniques)

  • 07.57.Pt
78.20.Ci (Optical constants (including refractive index, complex dielectric constant, absorption, reflection and transmission coefficients, emissivity)) 87.64.-t (Spectroscopic and microscopic techniques in biophysics and medical physics) 87.85.Pq (Biomedical imaging)