›› 2015, Vol. 24 ›› Issue (4): 44302-044302.doi: 10.1088/1674-1056/24/4/044302

• ELECTROMAGNETISM, OPTICS, ACOUSTICS, HEAT TRANSFER, CLASSICAL MECHANICS, AND FLUID DYNAMICS • 上一篇    下一篇

Relationships of the internodal distance of biological tissue with its sound velocity and attenuation at high frequency in doublet mechanics

程凯旋a, 吴融融a, 刘晓宙a b, 刘杰惠a, 龚秀芬a, 吴君汝c   

  1. a Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093, China;
    b State Key Laboratory of Acoustics, Institute of Acoustics, Chinese Academy of Sciences, Beijing 100190, China;
    c Department of Physics, University of Vermont, Burlington, Vermont 05405, USA
  • 收稿日期:2014-09-07 修回日期:2014-10-07 出版日期:2015-04-05 发布日期:2015-04-05
  • 基金资助:
    Project supported by the National Basic Research Program of China (Grant Nos. 2012CB921504 and 2011CB707902), the National Natural Science Foundation of China (Grant No. 11274166), the Fundamental Research Funds for the Central Universities, China (Grant Nos. 1113020403 and 1101020402), the State Key Laboratory of Acoustics, Chinese Academy of Sciences (Grant No. SKLA201401), the China Postdoctoral Science Foundation (Grant No. 2013M531313), the Priority Academic Program Development of Jiangsu Provincial Higher Education Institutions and Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry, and the Project of Interdisciplinary Center of Nanjing University, China (Grant No. NJUDC2012004).

Relationships of the internodal distance of biological tissue with its sound velocity and attenuation at high frequency in doublet mechanics

Cheng Kai-Xuan (程凯旋)a, Wu Rong-Rong (吴融融)a, Liu Xiao-Zhou (刘晓宙)a b, Liu Jie-Hui (刘杰惠)a, Gong Xiu-Fen (龚秀芬)a, Wu Jun-Ru (吴君汝)c   

  1. a Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093, China;
    b State Key Laboratory of Acoustics, Institute of Acoustics, Chinese Academy of Sciences, Beijing 100190, China;
    c Department of Physics, University of Vermont, Burlington, Vermont 05405, USA
  • Received:2014-09-07 Revised:2014-10-07 Online:2015-04-05 Published:2015-04-05
  • Contact: Liu Xiao-Zhou E-mail:xzliu@nju.edu.cn
  • Supported by:
    Project supported by the National Basic Research Program of China (Grant Nos. 2012CB921504 and 2011CB707902), the National Natural Science Foundation of China (Grant No. 11274166), the Fundamental Research Funds for the Central Universities, China (Grant Nos. 1113020403 and 1101020402), the State Key Laboratory of Acoustics, Chinese Academy of Sciences (Grant No. SKLA201401), the China Postdoctoral Science Foundation (Grant No. 2013M531313), the Priority Academic Program Development of Jiangsu Provincial Higher Education Institutions and Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry, and the Project of Interdisciplinary Center of Nanjing University, China (Grant No. NJUDC2012004).

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摘要： In view of the discrete characteristics of biological tissue, doublet mechanics has demonstrated its advantages in the mathematic description of tissue in terms of high frequency (>10 MHz) ultrasound. In this paper, we take human breast biopsies as an example to study the influence of the internodal distance, a microscope parameter in biological tissue in doublet mechanics, on the sound velocity and attenuation by numerical simulation. The internodal distance causes the sound velocity and attenuation in biological tissue to change with the increase of frequency. The magnitude of such a change in pathological tissue is distinctly different from that in normal tissue, which can be used to differentiate pathological tissue from normal tissue and can depict the diseased tissue structure by obtaining the sound and attenuation distribution in the sample at high ultrasound frequency. A comparison of sensitivity between the doublet model and conventional continuum model is made, indicating that this is a new method of characterizing ultrasound tissue and diagnosing diseases.

关键词: doublet mechanics, sound velocity, sound attenuation, ultrasound tissue characteristics

Abstract: In view of the discrete characteristics of biological tissue, doublet mechanics has demonstrated its advantages in the mathematic description of tissue in terms of high frequency (>10 MHz) ultrasound. In this paper, we take human breast biopsies as an example to study the influence of the internodal distance, a microscope parameter in biological tissue in doublet mechanics, on the sound velocity and attenuation by numerical simulation. The internodal distance causes the sound velocity and attenuation in biological tissue to change with the increase of frequency. The magnitude of such a change in pathological tissue is distinctly different from that in normal tissue, which can be used to differentiate pathological tissue from normal tissue and can depict the diseased tissue structure by obtaining the sound and attenuation distribution in the sample at high ultrasound frequency. A comparison of sensitivity between the doublet model and conventional continuum model is made, indicating that this is a new method of characterizing ultrasound tissue and diagnosing diseases.

Key words: doublet mechanics, sound velocity, sound attenuation, ultrasound tissue characteristics

中图分类号:  (Ultrasonics, quantum acoustics, and physical effects of sound)

  • 43.35.+d
43.80.+p (Bioacoustics)