Extended triplet set C343 of DNA sequences and its application to the p53 gene

doi:10.1088/1674-1056/20/1/018701

中国物理B ›› 2011, Vol. 20 ›› Issue (1): 18701-018701.doi: 10.1088/1674-1056/20/1/018701

Extended triplet set C₃₄₃ of DNA sequences and its application to the p53 gene

闫艳艳, 朱平

School of Science, Jiangnan University, Wuxi 214122, China

收稿日期:2010-05-16 修回日期:2010-08-09 出版日期:2011-01-15 发布日期:2011-01-15
基金资助:
Project supported in part by the Program for Innovative Research Team of Jiangnan University, China (Grant No. 2008 CX002).

Extended triplet set C₃₄₃ of DNA sequences and its application to the p53 gene

Yan Yan-Yan(闫艳艳) and Zhu Ping(朱平)^†

School of Science, Jiangnan University, Wuxi 214122, China

Received:2010-05-16 Revised:2010-08-09 Online:2011-01-15 Published:2011-01-15
Supported by:
Project supported in part by the Program for Innovative Research Team of Jiangnan University, China (Grant No. 2008 CX002).

摘要/Abstract

摘要： Recently, much research has indicated that more and more cancers pose a threat to human life. Cancers are caused by oncogenes. Many human oncogenes have been found and most of them are located on chromosomes. The discovery of the oncogene plays a significant role in the treatment of cancer. The p53 tumor suppressor gene has received much attention because it frequently mutates or deletes in tumor cells of most people. Thus, the study of oncogenes is significant. In order to establish the Galois field (GF(7)), the indefinite gene is introduced as D and oncogene is introduced as O, and P. Taking the polynomial coefficients a₀, a₁, a₂ ∈ GF(7) and the bijective function f:GF(7) → {D,A,C,O,G,T,P}, where f(0) = D, f(1) = A, f(2) = C, f(3) = O, f(4) = G, f(5) = T, and f(6) = P, the bijective φ may be written as φ(a₀ + a₁x + a₂x²). Based on the algebraic structure, we can not only analyse the DNA sequence of oncogenes, but also predict possible new cancers.

关键词: oncogene, gene encoding algebraic, polynomial, p53

Abstract: Recently, much research has indicated that more and more cancers pose a threat to human life. Cancers are caused by oncogenes. Many human oncogenes have been found and most of them are located on chromosomes. The discovery of the oncogene plays a significant role in the treatment of cancer. The p53 tumor suppressor gene has received much attention because it frequently mutates or deletes in tumor cells of most people. Thus, the study of oncogenes is significant. In order to establish the Galois field (GF(7)), the indefinite gene is introduced as D and oncogene is introduced as O, and P. Taking the polynomial coefficients a₀, a₁, a₂ ∈ GF(7) and the bijective function f:GF(7) → {D,A,C,O,G,T,P}, where f(0) = D, f(1) = A, f(2) = C, f(3) = O, f(4) = G, f(5) = T, and f(6) = P, the bijective φ may be written as φ(a₀ + a₁x + a₂x²). Based on the algebraic structure, we can not only analyse the DNA sequence of oncogenes, but also predict possible new cancers.

Key words: oncogene, gene encoding algebraic, polynomial, p53

中图分类号: (Structure of biomolecules)

87.15.B-

闫艳艳, 朱平. Extended triplet set C₃₄₃ of DNA sequences and its application to the p53 gene[J]. 中国物理B, 2011, 20(1): 18701-018701.

Yan Yan-Yan(闫艳艳) and Zhu Ping(朱平). Extended triplet set C₃₄₃ of DNA sequences and its application to the p53 gene[J]. Chin. Phys. B, 2011, 20(1): 18701-018701.

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Extended triplet set C₃₄₃ of DNA sequences and its application to the p53 gene

Extended triplet set C₃₄₃ of DNA sequences and its application to the p53 gene

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