Controlling intracellular Ca2+ spiral waves by the local agonist in the cell membrane

doi:10.1088/1674-1056/19/3/030508

中国物理B ›› 2010, Vol. 19 ›› Issue (3): 30508-030508.doi: 10.1088/1674-1056/19/3/030508

Controlling intracellular Ca²⁺ spiral waves by the local agonist in the cell membrane

唐军¹, 罗继明¹, 仇康², 马军³

(1)College of Science, China University of Mining and Technology, Xuzhou 221008, China; (2)Department of Mathematics and Physics, Xuzhou Medical College, Xuzhou 221004, China; (3)Department of Physics, Lanzhou University of Technology, Lanzhou 730050, China

收稿日期:2009-07-30 修回日期:2009-09-06 出版日期:2010-03-15 发布日期:2010-03-15
基金资助:
Project supported by the Xuzhou Medical College Foundation, China (Grant No.~08kj08).

Controlling intracellular Ca²⁺ spiral waves by the local agonist in the cell membrane

Qiu Kang(仇康)^a), Tang Jun(唐军)^b)†, Ma Jun(马军)^c), and Luo Ji-Ming(罗继明)^b)

^a Department of Mathematics and Physics, Xuzhou Medical College, Xuzhou 221004, China; ^b College of Science, China University of Mining and Technology, Xuzhou 221008, China; ^c Department of Physics, Lanzhou University of Technology, Lanzhou 730050, China

Received:2009-07-30 Revised:2009-09-06 Online:2010-03-15 Published:2010-03-15
Supported by:
Project supported by the Xuzhou Medical College Foundation, China (Grant No.~08kj08).

摘要/Abstract

摘要： A modified spatially extended Tang--Othmer Ca²⁺ model is used to study intracellular Ca²⁺ spiral waves numerically. It is found that, as a local stimulation, the local agonist-binding on the cell membrane，which enhances the local concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP₃), can influence the dynamics of the spiral waves. {1}) Strong enough stimuli can change the spiral wave from a meandering to a rigidly rotating one. {2}) On the other hand, strong enough stimuli can suppress the spiral wave from the system. It provides the theoretical clue for controlling the spiral waves by stimulating the cell membrane.

Abstract: A modified spatially extended Tang--Othmer Ca²⁺ model is used to study intracellular Ca²⁺ spiral waves numerically. It is found that, as a local stimulation, the local agonist-binding on the cell membrane，which enhances the local concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP₃), can influence the dynamics of the spiral waves. 1) Strong enough stimuli can change the spiral wave from a meandering to a rigidly rotating one. 2) On the other hand, strong enough stimuli can suppress the spiral wave from the system. It provides the theoretical clue for controlling the spiral waves by stimulating the cell membrane.

Key words: spiral wave, local stimuli, calcium signaling, IP₃

中图分类号: (Active transport processes)

87.16.Uv

87.16.D- (Membranes, bilayers, and vesicles) 87.16.A- (Theory, modeling, and simulations) 82.39.Wj (Ion exchange, dialysis, osmosis, electro-osmosis, membrane processes)

仇康, 唐军, 马军, 罗继明. Controlling intracellular Ca²⁺ spiral waves by the local agonist in the cell membrane[J]. 中国物理B, 2010, 19(3): 30508-030508.

Qiu Kang(仇康), Tang Jun(唐军), Ma Jun(马军), and Luo Ji-Ming(罗继明). Controlling intracellular Ca²⁺ spiral waves by the local agonist in the cell membrane[J]. Chin. Phys. B, 2010, 19(3): 30508-030508.

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Controlling intracellular Ca²⁺ spiral waves by the local agonist in the cell membrane

Controlling intracellular Ca²⁺ spiral waves by the local agonist in the cell membrane

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