中国物理B ›› 2006, Vol. 15 ›› Issue (5): 940-946.doi: 10.1088/1009-1963/15/5/012

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Single long-polymer translocation through a long pore

丁克俭, 蔡冬青, 詹福如, 吴李君, 吴跃进, 余增亮   

  1. The Key Laboratory of Ion-Beam Bioengineering, Institute of Plasma Physics,Chinese Academy of Sciences, Hefei 230031, China
  • 收稿日期:2005-11-07 修回日期:2005-12-25 出版日期:2006-05-20 发布日期:2006-05-20
  • 基金资助:
    Project supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No KSCX2-SW-324), and the National Science Fund for Distinguished Young Scholars, China (Grant No 10225526).

Single long-polymer translocation through a long pore

Ding Ke-Jian (丁克俭), Cai Dong-Qing (蔡冬青), Zhan Fu-Ru (詹福如), Wu Li-Jun (吴李君), Wu Yue-Jin (吴跃进), Yu Zeng-Liang (余增亮)   

  1. The Key Laboratory of Ion-Beam Bioengineering, Institute of Plasma Physics,Chinese Academy of Sciences, Hefei 230031, China
  • Received:2005-11-07 Revised:2005-12-25 Online:2006-05-20 Published:2006-05-20
  • Supported by:
    Project supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No KSCX2-SW-324), and the National Science Fund for Distinguished Young Scholars, China (Grant No 10225526).

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摘要： This paper theoretically studies the free energy and conformational entropy of a long polymer threading a long nanopore (n0/N \ge 0.1) on external electric field. The polymer expanded model is built in this paper, that is, a single long polymer chain with N monomers (each of size a) threading a pore with n0 monomers can be regarded as polymer with N+n_{0} monomers translocating a 2-dimension hole embedded in membrane. A theoretical approach is presented which explicitly takes into account the nucleation theory. Our calculations imply that, the structure of polymer changes more acutely than other situation, while its leading monomer reaches the second vacuum and its end monomer escapes the first vacuum. And it is also shown that the length scale of polymer and pore play a very important role for polymer translocation dynamics. The present model predicts that the translocation time depends on the chemical potential gradient and the property of the solvent on sides of pore to some extent.

关键词: polymer expansion, nucleation theory, conformational entropy, translocation time

Abstract: This paper theoretically studies the free energy and conformational entropy of a long polymer threading a long nanopore ($n_0/N\geq 0.1$) on external electric field. The polymer expanded model is built in this paper, that is, a single long polymer chain with N monomers (each of size a) threading a pore with n0 monomers can be regarded as polymer with $N+n_{0}$ monomers translocating a 2-dimension hole embedded in membrane. A theoretical approach is presented which explicitly takes into account the nucleation theory. Our calculations imply that, the structure of polymer changes more acutely than other situation, while its leading monomer reaches the second vacuum and its end monomer escapes the first vacuum. And it is also shown that the length scale of polymer and pore play a very important role for polymer translocation dynamics. The present model predicts that the translocation time depends on the chemical potential gradient and the property of the solvent on sides of pore to some extent.

Key words: polymer expansion, nucleation theory, conformational entropy, translocation time

中图分类号:  (Nucleic acids)

  • 87.14.G-
87.15.B- (Structure of biomolecules) 87.15.H- (Dynamics of biomolecules)