中国物理B ›› 2003, Vol. 12 ›› Issue (2): 226-230.doi: 10.1088/1009-1963/12/2/320

• • 上一篇    

Interactions between DNA and histones－ a dynamic process of nucleosome formation

童培庆1, 王鹏业2, 窦硕星2, 李伟3   

  1. (1)Department of Physics, Nanjing Normal University, Nanjing 210097, China; (2)Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China; (3)Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China; Department of Physics, Nanjing Normal University, Nanjing 210097, China
  • 收稿日期:2002-09-13 修回日期:2002-10-14 出版日期:2003-02-16 发布日期:2005-03-16
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant No 60025516).

Interactions between DNA and histones－ a dynamic process of nucleosome formation

Li Wei (李伟)ab, Wang Peng-Ye (王鹏业)a, Dou Shuo-Xing (窦硕星)a, Tong Pei-Qing (童培庆)b   

  1. a Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China; b Department of Physics, Nanjing Normal University, Nanjing 210097, China
  • Received:2002-09-13 Revised:2002-10-14 Online:2003-02-16 Published:2005-03-16
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant No 60025516).

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摘要： We have studied the dynamic process of interactions between a DNA chain and a histone octamer by numerical simulations. It is found that DNA indeed may wrap around the histone octamer about two turns as in the actual situations. The simulation shows that the interaction potential between DNA and histone is a key factor for the wrapping of DNA, and the temperature is also an important parameter in the process.

Abstract: We have studied the dynamic process of interactions between a DNA chain and a histone octamer by numerical simulations. It is found that DNA indeed may wrap around the histone octamer about two turns as in the actual situations. The simulation shows that the interaction potential between DNA and histone is a key factor for the wrapping of DNA, and the temperature is also an important parameter in the process.

Key words: DNA, histone, nucleosome, interaction

中图分类号:  (Chromosomes, histones)

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