Effect of 3.1-THz radiation on pathological progression in Caenorhabditis elegans Alzheimer’s disease model

Terahertz (THz) radiation, an emerging frequency band of the electromagnetic spectrum, has been widely applied across various fields. However, its ability to resonate with the energy levels of biomolecules has raised significant concerns regarding its biosafety. A growing body of research indicates that THz radiation can markedly influence the structure and function of proteins. Alzheimer’s disease (AD), a neurodegenerative disorder characterized by the abnormal aggregation of amyloid proteins, has been shown in prior studies to be modulated by THz radiation in terms of amyloid aggregation. Building on this, the present study utilized the CL4176 strain of Caenorhabditis elegans as an animal model for AD. Using a self-designed and constructed radiation system based on quantum cascade lasers, the study investigated changes in the pathological progression of AD under 3.1-THz electromagnetic radiation exposure. By evaluating lifespan, motility, feeding behavior, reactive oxygen species (ROS) levels, and aging markers in the Caenorhabditis elegans model, the study highlights the potential biological risks of 3.1-THz radiation for individuals with AD. These findings provide crucial experimental evidence to support the promotion and standardization of THz technology applications.