Rotational manipulation of massive particles in a 2D acoustofluidic chamber constituted by multiple nonlinear vibration sources

Rotational manipulation of massive particles and biological samples is essential for the development of miniaturized lab-on-a-chip platforms in the fields of chemical, medical, and biological applications. In this paper, a device concept of a two-dimensional acoustofluidic chamber actuated by multiple nonlinear vibration sources is proposed. The functional chamber enables the generation of acoustic streaming vortices for potential applications that include strong mixing of multi-phase flows and rotational manipulation of micro-/nano-scale objects without any rotating component. Using numerical simulations, we find that diversified acoustofluidic fields can be generated in the chamber under various actuations, and massive polystyrene beads inside can experience different acoustophoretic motions under the combined effect of an acoustic radiation force and acoustic streaming. Moreover, we investigate and clarify the effects of structural design on modulation of the acoustofluidic fields in the chamber. We believe the presented study could not only provide a promising potential tool for rotational acoustofluidic manipulation, but could also bring this community some useful design insights into the achievement of desired acoustofluidic fields for assorted microfluidic applications.