Gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging for detection of submucosal gastric cancer: in vitro study

This paper presents photoacoustic and ultrasonic dual-mode imaging for real-time detection of submucosal gastric cancer with a combination of gastroscopy. The diagnostic capacity was directly addressed via several phantoms and ex vivo experiments. Results demonstrated that superficial and submucosal gastric cancer can be diagnosed with a perceptible depth of 6.33 mm, a lateral accuracy of 2.23 mm, and a longitudinal accuracy of 0.17 mm though capturing the morphology of angiogenesis, which is a main character of the therioma-related change. The capability of gastroscopy-conjugated photoacoustic and ultrasonic dual-mode imaging system will own great potential in improving the clinical diagnostic rate of submucosal gastric cancer.