Phase diagram for epistatic fitness recovery with DCA-nMF J_ij’s from the average of singletime data. (a) Mutation rate μ versus recombination rate r. For large recombination while low mutation, KNS inference does not work. However, for small r, the KNS inference theory does not satisfied. (b) Epistatic fitness strength σ with r. For large recombination and very small fitness, KNS inference does not work.