Astrocyte and ions metabolism during epileptogenesis: A review for modeling studies Project supported by the National Natural Science Foundation of China (Grant No. 11772242). |
Schematic diagram of lactate transmission in the neuron–astrocyte–capillary loop. Glucose can be transported through astrocyte capillaries and then transmitted into distant astrocytes by gap junctions. Afterwards, the transmitted glucose is degraded into lactate by lactate dehydrogenase in astrocytes. Finally, this lactate can be absorbed by neurons to sustain action potentials. |