Phase transition of DNA compaction in confined space: Effects of macromolecular crowding are dominant<xref rid="cpb_29_1_018701fn1" ref-type="fn">*</xref> <fn id="cpb_29_1_018701fn1"> <label>*</label> <p>Project supported by the National Natural Science Foundation of China (Grant Nos. 11464004 and 11864006), the State Scholarship Fund, China (Grant No. 20173015) and Guizhou Scientific and Technological Program, China (Grant No. 20185781).</p> </fn>

Phase transition of DNA compaction in confined space: Effects of macromolecular crowding are dominant* *

Project supported by the National Natural Science Foundation of China (Grant Nos. 11464004 and 11864006), the State Scholarship Fund, China (Grant No. 20173015) and Guizhou Scientific and Technological Program, China (Grant No. 20185781).

Chen Erkun¹, Fan Yangtao², Zhao Guangju¹, Mao Zongliang¹, Zhou Haiping^{3, ‡}, Liu Yanhui^{1, §}

Effects of temperature on the phase transition of condensed DNA in confined spherical space without crowders. (a) The phase transition of condensed DNA with contour length 299.0 nm in confined spherical space with radius ranging from 20.0 nm to 57.0 nm and the relation between the radius of confined spherical space and the temperature corresponding to the phase transition is indicated in the inset. (b) The autocorrelation of the conformation of condensed DNA with contour length 299.0 nm in confined spherical space with radius 20.0 nm before and after phase transition, the autocorrelation after phase transition shifts left as compared with the one before.