Quantitative heterogeneity and subgroup classification based on motility of breast cancer cells

Xiong Ling¹, Liu Yanping^{1, 2}, Liu Ruchuan¹, Yuan Wei³, Wang Gao¹, He Yi¹, Shuai Jianwei², Jiao Yang⁴, Zhang Xixiang⁵, Han Weijing⁶, Qu Junle^{3, ‡}, Liu Liyu^{1, §}

Persistent time of cells in EGF+ medium with and ratio of active cells. (a)–(f) Histograms of persistence times from maximum likelihood estimation fitting of power spectra for MDA-MB-231 (blue) and MCF-7 (red) cells: (a) and (d) persistent time of normal cells, (b) and (e) short persistent time component of active cells, (c) and (f) long persistent time component of active cells. (g) Ratio of active cells in four media types for MDA-MB-231 (blue) and MCF-7 (red) cells.