Volcano plots of gene expression profiles in (a) RPE, (b) HCE, and (c) Müller cells. Fold change of expression magnitude is plotted versus level of statistical significance (transformed into a logarithmic scale). Note that red, green and gray color represent genes whose expression is considered up-regulated, down-regulated and unchanged, respectively. Besides, triangles represent the DEGs with FDR-adjusted p-value ⩽ 0.05 . Complete lists of DEGs, and corresponding fold change of expression and p-value are given in Data File 1.