Intrinsic fluctuation and susceptibility in somatic cell reprogramming process

Shen Jian¹, Zhang Xiaomin^{1, 2}, Li Qiliang¹, Wang Xinyu¹, Zhao Yunjie¹, Jia Ya^{1, †}

Intrinsic noises of the expression levels of key genes X, Y, and Z versus the self-activation ratios α i (i = X, Y, Z). The lines are the Fano factor from theoretical formulas Eqs. (18)–(20), and the dots are the results of Fano factor from Gillespie algorithm with size parameter Ω = 3000 .