Intrinsic fluctuation and susceptibility in somatic cell reprogramming process

Shen Jian¹, Zhang Xiaomin^{1, 2}, Li Qiliang¹, Wang Xinyu¹, Zhao Yunjie¹, Jia Ya^{1, †}

Intrinsic noises of gene expression levels of key genes X, Y, and Z versus the activated ratios k i ( i = k S 1 , k S 2 , X, Y) by upstream transcription factors. The lines are the Fano factor from theoretical formulas Eqs. (18)–(20), and the dots are the results of Fano factor from the Gillespie algorithm with size parameter Ω = 3000 .