Intrinsic fluctuation and susceptibility in somatic cell reprogramming process

Shen Jian¹, Zhang Xiaomin^{1, 2}, Li Qiliang¹, Wang Xinyu¹, Zhao Yunjie¹, Jia Ya^{1, †}

Scheme of coherent feedforward transcription regulation loops in somatic cell reprogramming process. S denotes the exogenous OSKM (Oct4, Sox2, Klf4, and c-Myc) factors, X represents the earliest pluripotency genes (such as the AP), Y represents the pluripotency genes (such as the SSEA-1), and Z denotes the endogenous pluripotency genes (Nanog, Oct4, and Sox2).