Controlled generation of cell–laden hydrogel microspheres with core–shell scaffold mimicking microenvironment of tumor<xref rid="cpb_27_12_128703_fn1" ref-type="fn">*</xref><fn id="cpb_27_12_128703_fn1"><label>*</label><p>Project supported by the National Natural Science Foundation of China (Grant Nos. 11474345, 11674043, and 11604030) and the Fundamental and Advanced Research Program of Chongqing (Grant No. cstc2018jcyjAX0338).</p></fn>

Controlled generation of cell–laden hydrogel microspheres with core–shell scaffold mimicking microenvironment of tumor**

Project supported by the National Natural Science Foundation of China (Grant Nos. 11474345, 11674043, and 11604030) and the Fundamental and Advanced Research Program of Chongqing (Grant No. cstc2018jcyjAX0338).

Li Yuenan¹, Hai Miaomiao¹, Zhao Yu², Lv Yalei¹, He Yi¹, Chen Guo¹, Liu Liyu¹, Liu Ruchuan^{1, ‡}, Zhang Guigen^{2, §}

(color online) Droplets with variable volume ratios of the core and shell are generated. (a) The lower ratio of V_Fluorescein to V_Alginate (V_A2:V_A1), the narrower fluorescein flow. (b) The distribution of the fluorescence intensity over the channel cross-section in the co-flow area (Fig. 4(a), red arrow) at different ratio of V_Fluorescein to V_Alginate. (c) Statistical results show that droplet size slightly decreases with reduced ratio of V_Fluorescein to V_Alginate.