Efficiency of collective myosin II motors studied with an elastic coupling power-stroke ratchet model*
Project supported by the Key Research Program of Frontier Sciences of Chinese Academy of Sciences (Grant No. Y7Y1472Y61), the National Natural Science Foundation of China (Grant Nos. 11205123, 11574329, 11774358, 11747601, and 11675017), the Joint NSFC-ISF Research Program (Grant
No. 51561145002), the CAS Biophysics Interdisciplinary Innovation Team Project (Grant No. 2060299), the CAS Strategic Priority Research Program (Grant No. XDA17010504), and the Fundamental Research Funds for the Central Universities (Grant No. 2017EYT24).
Wang Zi-Qing1, Li Jin-Fang1, Xie Ying-Ge1, Wang Guo-Dong1, Shu Yao-Gen2, †
(color online) (a) The efficiency of collective motor {vs} velocity for different motor stiffness at s−1.[11,41] The symbols are experimental data of EDL muscle (fast muscle).[21] The short dashed-dotted line is the efficiency of Model II under consideration of friction (λ0 = 0.005 pN.s/μm), while the long dashed-dotted line is that without friction. The solid line at the lower left corner is calculated by Model I with b/l = 0.1, which is much more smaller than that is calculated by Model II. (b) The efficiency of collective motor vs velocity for different at km = 3 pN/nm. The symbols are experimental data of Soleus (slow muscle).[21] Here, ΔE =60 pN.nm[42] < ΔGATP ≈ 80pN.nm, ΔHATP ≈ 80 pN.nm,[43,44] Δε = 5 pN.nm,[32]Fd = 3 pN,[39] Δz = l/10, and l = 10 nm, ωon = 20 s–1 in Model I,[12] while s−1 in Model II due to l/Δz = 10, and D ≈ 106 nm2/s.[42]
