Probing conformational change of T7 RNA polymerase and DNA complex by solid-state nanopores

Tong Xin¹, Hu Rui¹, Li Xiaoqing¹, Zhao Qing^{1, 2, †}

(color online) Color contour plots of vs log dwell-time (t_d) for T7 1142 events (a) and complex 1214 events (b) with a 10 nm nanopore and applied voltage of 100 mV. Histograms of for T7 (c) and complex (d) events. The histograms are fitted with Gaussian distributions (blue curves).