Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound<xref rid="cpb_27_7_078701fn1" ref-type="fn">*</xref><fn id="cpb_27_7_078701fn1"><label>*</label><p>Project supported by the National Natural Science Foundation of China (Grant No. 81272495) and the Natural Science Foundation of Tianjin, China (Grant No. 16JC2DJC32200).</p></fn>

Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound**

Project supported by the National Natural Science Foundation of China (Grant No. 81272495) and the Natural Science Foundation of Tianjin, China (Grant No. 16JC2DJC32200).

Chang Shi-Hui¹, Cao Rui², Zhang Ya-Bin^{1, 3}, Wang Pei-Guo⁴, Wu Shi-Jing¹, Qian Yu-Han¹, Jian Xi-Qi^{1, †}

(color online) (a) Variations of Δ_zT with Δt under different L values (P_w = 103.05 W), (b) Variations of ΔT_m with L and (c) variation of TFR volume with Δt for different L values, with uniform temperature in the focal region, and maximum temperature of 65 °C.