Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound*

Project supported by the National Natural Science Foundation of China (Grant No. 81272495) and the Natural Science Foundation of Tianjin, China (Grant No. 16JC2DJC32200).
Chang Shi-Hui1, Cao Rui2, Zhang Ya-Bin1, 3, Wang Pei-Guo4, Wu Shi-Jing1, Qian Yu-Han1, Jian Xi-Qi1, †
       

(color online) Temperature distributions with L = 10.0 mm, Δt = 400 ns and Pw = 103.05 W when the maximum temperature reached 65 °C. (a) Temperature along the acoustic axis with M = 0.50 and M = 0.46. (b) Temperature distribution of the y–z plane of x = 0 with M = 0.46.