Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound<xref rid="cpb_27_7_078701fn1" ref-type="fn">*</xref><fn id="cpb_27_7_078701fn1"><label>*</label><p>Project supported by the National Natural Science Foundation of China (Grant No. 81272495) and the Natural Science Foundation of Tianjin, China (Grant No. 16JC2DJC32200).</p></fn>

Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound**

Project supported by the National Natural Science Foundation of China (Grant No. 81272495) and the Natural Science Foundation of Tianjin, China (Grant No. 16JC2DJC32200).

Chang Shi-Hui¹, Cao Rui², Zhang Ya-Bin^{1, 3}, Wang Pei-Guo⁴, Wu Shi-Jing¹, Qian Yu-Han¹, Jian Xi-Qi^{1, †}

(color online) Modulated results with the targets set to be off axis (P_w = 103.05 W), showing (a) temperature distribution on the x–z plane of y = 0, along the z direction and along the x direction across the position of maximum temperature for targets set to be at (−1, 0, 75), (−1, 0, 82.5), and (b) temperature distribution on the y–z plane of x = 0, along the z direction and along the y direction across position of maximum temperature with targets set to be (0, −1, 75) and (0, −1, 82.5).