Interaction between human telomeric G-quadruplexes characterized by single molecule magnetic tweezers<xref rid="cpb_27_6_068701_fn1" ref-type="fn">*</xref> <fn id="cpb_27_6_068701_fn1"> <label>*</label> <p>Project supported by the National Natural Science Foundation of China (Grant Nos. 11474346 and 11774407), the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (Grant No. QYZDB-SSW-SLH045), and the National Key Research and Development Program, China (Grant No. 2016YFA0301500).</p> </fn>

Interaction between human telomeric G-quadruplexes characterized by single molecule magnetic tweezers* *

Project supported by the National Natural Science Foundation of China (Grant Nos. 11474346 and 11774407), the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (Grant No. QYZDB-SSW-SLH045), and the National Key Research and Development Program, China (Grant No. 2016YFA0301500).

Wang Yi-Zhou^{1, 3}, Hou Xi-Miao², Ju Hai-Peng¹, Xiao Xue^{1, 3}, Xi Xu-Guang², Dou Shuo-Xing^{1, 3}, Wang Peng-Ye^{1, 3, ‡}, Li Wei^{1, §}

(color online) Folding and unfolding kinetics of two G-quadruplexes in wtTel45 sequence. (a) Trajectory (upper panel) under different constant forces (lower panel) showing two ruptures of G-quadruplex. (b) Relationships between reaction rate k_u, k_f, and tension F. The equilibrium tension F_eq can be read from the point where k_u = k_f. The error bars reflect a ∼ 10% error in force determination. (c) Different folding and unfolding kinetics of two G-quadruplex near F_eq. For the first G-quadruplex, τ₀ = 20.5 s (left panel) and for the second G-quadruplex, τ₀ = 4.0 s (right panel).