Interaction between human telomeric G-quadruplexes characterized by single molecule magnetic tweezers<xref rid="cpb_27_6_068701_fn1" ref-type="fn">*</xref> <fn id="cpb_27_6_068701_fn1"> <label>*</label> <p>Project supported by the National Natural Science Foundation of China (Grant Nos. 11474346 and 11774407), the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (Grant No. QYZDB-SSW-SLH045), and the National Key Research and Development Program, China (Grant No. 2016YFA0301500).</p> </fn>

Interaction between human telomeric G-quadruplexes characterized by single molecule magnetic tweezers* *

Project supported by the National Natural Science Foundation of China (Grant Nos. 11474346 and 11774407), the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (Grant No. QYZDB-SSW-SLH045), and the National Key Research and Development Program, China (Grant No. 2016YFA0301500).

Wang Yi-Zhou^{1, 3}, Hou Xi-Miao², Ju Hai-Peng¹, Xiao Xue^{1, 3}, Xi Xu-Guang², Dou Shuo-Xing^{1, 3}, Wang Peng-Ye^{1, 3, ‡}, Li Wei^{1, §}

(color online) Force ramp experiments of dimeric G-quadruplexes and mono G-quadruplex. (a) Typical force responses of dual G-quadruplexes in a stretching cycle (upper panel) with a loading rate of 16 pN/s (lower panel). (b) Unfolding force distribution of the first G-quadruplex in the dimeric G-quadruplexes fitted with Evans model (upper panel, N = 200) and monomeric G-quadruplex (lower panel, N = 198).