Interaction between human telomeric G-quadruplexes characterized by single molecule magnetic tweezers<xref rid="cpb_27_6_068701_fn1" ref-type="fn">*</xref> <fn id="cpb_27_6_068701_fn1"> <label>*</label> <p>Project supported by the National Natural Science Foundation of China (Grant Nos. 11474346 and 11774407), the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (Grant No. QYZDB-SSW-SLH045), and the National Key Research and Development Program, China (Grant No. 2016YFA0301500).</p> </fn>

Interaction between human telomeric G-quadruplexes characterized by single molecule magnetic tweezers* *

Project supported by the National Natural Science Foundation of China (Grant Nos. 11474346 and 11774407), the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (Grant No. QYZDB-SSW-SLH045), and the National Key Research and Development Program, China (Grant No. 2016YFA0301500).

Wang Yi-Zhou^{1, 3}, Hou Xi-Miao², Ju Hai-Peng¹, Xiao Xue^{1, 3}, Xi Xu-Guang², Dou Shuo-Xing^{1, 3}, Wang Peng-Ye^{1, 3, ‡}, Li Wei^{1, §}

(color online) (a) Schematic setup of magnetic tweezers (not to scale). The 45 nt wtTel45 sequence is tethered between a coverslip and a superparamagnetic bead with two 699 bp and 2271 bp dsDNA handles. (b) Typical trajectory with two distinct ruptures indicate two stable G-quadruplexes formed in wtTel45 sequence.