Interaction between human telomeric G-quadruplexes characterized by single molecule magnetic tweezers Project supported by the National Natural Science Foundation of China (Grant Nos. 11474346 and 11774407), the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (Grant No. QYZDB-SSW-SLH045), and the National Key Research and Development Program, China (Grant No. 2016YFA0301500). |
(color online) (a) Schematic setup of magnetic tweezers (not to scale). The 45 nt wtTel45 sequence is tethered between a coverslip and a superparamagnetic bead with two 699 bp and 2271 bp dsDNA handles. (b) Typical trajectory with two distinct ruptures indicate two stable G-quadruplexes formed in wtTel45 sequence. |
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