Protection-against-water-attack determined difference between strengths of backbone hydrogen bonds in kinesin’s neck zipper region
Qin Jing-Yu1, 2, Geng Yi-Zhao3, 4, Lü Gang5, Ji Qing3, 4, 6, †, Fang Hai-Ping1, ‡
       

(color online) Two-sided protection of HB4 from water attacking. (a) Hydrophobic cover at A side of HB4 formed by Tyr78, Leu224, Val333, and Leu335. (b) Hydrogen bonding sites (black arrows) around HB4 at B side that prevents water molecules attacking the donor and acceptor of HB4 directly.