Protection-against-water-attack determined difference between strengths of backbone hydrogen bonds in kinesin’s neck zipper region

Qin Jing-Yu^{1, 2}, Geng Yi-Zhao^{3, 4}, Lü Gang⁵, Ji Qing^{3, 4, 6, †}, Fang Hai-Ping^{1, ‡}

(color online) Residue structures of the A and B sides of HB3. (a) Hydrophobic cover at A side of HB3 formed by Leu224, Val333, and Leu335. (b) Open water attack channel at B side of HB3 that allows water molecule to attack HB3 easily.